Piperidine CD4-mimetic compounds expose vulnerable Env epitopes sensitizing HIV-1-infected cells to ADCC

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The ability of HIV-1 accessory proteins Nef and Vpu to decrease CD4 levels contributes to the protection of infected cells from antibody-dependent cellular cytotoxicity (ADCC) by preventing the exposure of Env vulnerable epitopes. Small-molecule CD4 mimetics (CD4mc) based on the indane and piperidin...

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Detalles Bibliográficos
Autores principales: Ding, Shilei, Tolbert, William D., Zhu, Huile, Lee, Daniel, Higgins, Tyler, Zhao, Xuchen, Nguyen, Dung, Sherburn, Rebekah, Richard, Jonathan, Lepage, Gabrielle-Gendron, Medjahed, Halima, Mohammadi, Mohammadjavad, Abrams, Cameron, Pazgier, Marzena, Smith, Amos B., Finzi, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055368/
https://www.ncbi.nlm.nih.gov/pubmed/36993184
http://dx.doi.org/10.1101/2023.03.23.533923
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