CDH1 loss promotes diffuse-type gastric cancer tumorigenesis via epigenetic reprogramming and immune evasion

Diffuse-type gastric adenocarcinoma (DGAC) is a deadly cancer often diagnosed late and resistant to treatment. While hereditary DGAC is linked to CDH1 gene mutations, causing E-Cadherin loss, its role in sporadic DGAC is unclear. We discovered CDH1 inactivation in a subset of DGAC patient tumors. An...

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Detalles Bibliográficos
Autores principales: Zou, Gengyi, Huang, Yuanjian, Zhang, Shengzhe, Ko, Kyung-Pil, Kim, Bongjun, Zhang, Jie, Venkatesan, Vishwa, Pizzi, Melissa P., Fan, Yibo, Jun, Sohee, Niu, Na, Wang, Huamin, Song, Shumei, Ajani, Jaffer A., Park, Jae-Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055394/
https://www.ncbi.nlm.nih.gov/pubmed/36993615
http://dx.doi.org/10.1101/2023.03.23.533976

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