The ER membrane protein complex governs lysosomal turnover of a mitochondrial tail-anchored protein, BNIP3, to restrict mitophagy

Lysosomal degradation of autophagy receptors is a common proxy for selective autophagy. However, we find that two established mitophagy receptors, BNIP3 and BNIP3L/NIX, violate this assumption. Rather, BNIP3 and NIX are constitutively delivered to lysosomes in an autophagy-independent manner. This a...

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Detalles Bibliográficos
Autores principales: Delgado, Jose M, Wallace Shepard, Logan, Lamson, Sarah W, Liu, Samantha L, Shoemaker, Christopher J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055395/
https://www.ncbi.nlm.nih.gov/pubmed/36993512
http://dx.doi.org/10.1101/2023.03.22.533681

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055395/
https://www.ncbi.nlm.nih.gov/pubmed/36993512
http://dx.doi.org/10.1101/2023.03.22.533681

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