Endothelial Cell SMAD6 Balances ACVRL1/Alk1 Function to Regulate Adherens Junctions and Hepatic Vascular Development

BMP signaling is critical to blood vessel formation and function, but how pathway components regulate vascular development is not well-understood. Here we find that inhibitory SMAD6 functions in endothelial cells to negatively regulate ALK1/ACVRL1-mediated responses, and it is required to prevent ve...

Descripción completa

Detalles Bibliográficos
Autores principales: Kulikauskas, Molly R, Oatley, Morgan, Yu, Tianji, Liu, Ziqing, Matsumura, Lauren, Kidder, Elise, Ruter, Dana, Bautch, Victoria L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055411/
https://www.ncbi.nlm.nih.gov/pubmed/36993438
http://dx.doi.org/10.1101/2023.03.23.534007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055411/
https://www.ncbi.nlm.nih.gov/pubmed/36993438
http://dx.doi.org/10.1101/2023.03.23.534007

Ejemplares similares