Mapping the neutralizing specificity of human anti-HIV serum by deep mutational scanning

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Understanding the specificities of human serum antibodies that broadly neutralize HIV can inform prevention and treatment strategies. Here we describe a deep mutational scanning system that can measure the effects of combinations of mutations to HIV envelope (Env) on neutralization by antibodies and...

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Detalles Bibliográficos
Autores principales: Radford, Caelan E., Schommers, Philipp, Gieselmann, Lutz, Crawford, Katharine H. D., Dadonaite, Bernadeta, Yu, Timothy C., Dingens, Adam S., Overbaugh, Julie, Klein, Florian, Bloom, Jesse D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055425/
https://www.ncbi.nlm.nih.gov/pubmed/36993197
http://dx.doi.org/10.1101/2023.03.23.533993
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