Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells

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CRISPR-Cas9 genome editing has enabled advanced T cell therapies, but occasional loss of the targeted chromosome remains a safety concern. To investigate whether Cas9-induced chromosome loss is a universal phenomenon and evaluate its clinical significance, we conducted a systematic analysis in prima...

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Detalles Bibliográficos
Autores principales: Tsuchida, Connor A., Brandes, Nadav, Bueno, Raymund, Trinidad, Marena, Mazumder, Thomas, Yu, Bingfei, Hwang, Byungjin, Chang, Christopher, Liu, Jamin, Sun, Yang, Hopkins, Caitlin R., Parker, Kevin R., Qi, Yanyan, Satpathy, Ansuman T., Stadtmauer, Edward A., Cate, Jamie H.D., Eyquem, Justin, Fraietta, Joseph A., June, Carl H., Chang, Howard Y., Ye, Chun Jimmie, Doudna, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055432/
https://www.ncbi.nlm.nih.gov/pubmed/36993359
http://dx.doi.org/10.1101/2023.03.22.533709
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