Unique pharmacodynamic properties and low abuse liability of the μ-opioid receptor ligand (S)-methadone

(R,S)-methadone ((R,S)-MTD) is a racemic μ-opioid receptor (MOR) agonist comprised of (R)-MTD and (S)-MTD enantiomers used for the treatment of opioid use disorder (OUD) and pain. (R)-MTD is used as an OUD treatment, has high MOR potency, and is believed to mediate (R,S)-MTD’s therapeutic efficacy....

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Detalles Bibliográficos
Autores principales: Michaelides, Michael, Levinstein, Marjorie, De Oliveira, Paulo, Casajuana-Martin, Nil, Quiroz, Cesar, Budinich, Reece, Rais, Rana, Rea, William, Ventriglia, Emilya, Llopart, Natàlia, Casadó-Anguera, Verònica, Moreno, Estefanía, Walther, Donna, Glatfelter, Grant, Weinshenker, David, Zarate, Carlos, Casado, Vicent, Baumann, Michael, Pardo, Leonardo, Ferre, Sergi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055532/
https://www.ncbi.nlm.nih.gov/pubmed/36993715
http://dx.doi.org/10.21203/rs.3.rs-2644719/v1

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