VMAP: Vaginal Microbiome Atlas During Pregnancy

The vaginal microbiome has been shown to be associated with pregnancy outcomes including preterm birth (PTB) risk. Here we present VMAP: Vaginal Microbiome Atlas during Pregnancy (http://vmapapp.org), an application to visualize features of 3,909 vaginal microbiome samples of 1,416 pregnant individu...

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Detalles Bibliográficos
Autores principales: Parraga-Leo, Antonio, Oskotsky, Tomiko T., Oskotsky, Boris, Wibrand, Camilla, Roldan, Alennie, Tang, Alice, Ha, Connie W.Y., Wong, Ronald J., Minot, Samuel S., Andreoletti, Gaia, Kosti, Idit, Theis, Kevin R., Ng, Sherrianne, Lee, Yun S., Diaz-Gimeno, Patricia, Bennett, Phillip R., MacIntyre, David A., Lynch, Susan V., Romero, Roberto, Tarca, Adi L., Stevenson, David K., Aghaeepour, Nima, Golob, Jonathan, Sirota, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055588/
https://www.ncbi.nlm.nih.gov/pubmed/36993193
http://dx.doi.org/10.1101/2023.03.21.23286947
Descripción
Sumario:The vaginal microbiome has been shown to be associated with pregnancy outcomes including preterm birth (PTB) risk. Here we present VMAP: Vaginal Microbiome Atlas during Pregnancy (http://vmapapp.org), an application to visualize features of 3,909 vaginal microbiome samples of 1,416 pregnant individuals from 11 studies, aggregated from raw public and newly generated sequences via an open-source tool, MaLiAmPi. Our visualization tool (http://vmapapp.org) includes microbial features such as various measures of diversity, VALENCIA community state types (CST), and composition (via phylotypes and taxonomy). This work serves as a resource for the research community to further analyze and visualize vaginal microbiome data in order to better understand both healthy term pregnancies and those associated with adverse outcomes.

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