Reduction of human Alzheimer’s disease risk and reversal of mouse model cognitive deficit with nucleoside analog use

Innate immune signaling through the NLRP3 inflammasome has been implicated in the pathogenesis of Alzheimer’s disease (AD), the most prevalent form of dementia. We previously demonstrated that nucleoside reverse transcriptase inhibitors (NRTIs), drugs approved to treat HIV and hepatitis B infections...

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Detalles Bibliográficos
Autores principales: Magagnoli, Joseph, Yerramothu, Praveen, Ambati, Kameshwari, Cummings, Tammy, Nguyen, Joseph, Thomas, Claire C., Wang, Shao-bin, Cheng, Kaitlyn, Juraev, Maksud, Dholkawala, Roshni, Nagasaka, Ayami, Ambati, Meenakshi, Nagasaka, Yosuke, Ban, Ashley, Ambati, Vidya L., Sutton, S. Scott, Gelfand, Bradley D., Ambati, Jayakrishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055589/
https://www.ncbi.nlm.nih.gov/pubmed/36993694
http://dx.doi.org/10.1101/2023.03.17.23287375

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