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Evolution of promoter-proximal pausing enabled a new layer of transcription control
Promoter-proximal pausing of RNA polymerase II (Pol II) is a key regulatory step during transcription. Despite the central role of pausing in gene regulation, we do not understand the evolutionary processes that led to the emergence of Pol II pausing or its transition to a rate-limiting step activel...
Autores principales: | Chivu, Alexandra G., Abuhashem, Abderhman, Barshad, Gilad, Rice, Edward J., Leger, Michelle M., Vill, Albert C., Wong, Wilfred, Brady, Rebecca, Smith, Jeramiah J., Wikramanayake, Athula H., Arenas-Mena, César, Brito, Ilana L., Ruiz-Trillo, Iñaki, Hadjantonakis, Anna-Katerina, Lis, John T., Lewis, James J., Danko, Charles G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Journal Experts
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055653/ https://www.ncbi.nlm.nih.gov/pubmed/36993251 http://dx.doi.org/10.21203/rs.3.rs-2679520/v1 |
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