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2-Deoxyglucose and hydroxychloroquine HPLC-MS-MS analytical methods and pharmacokinetic interactions after oral co-administration in male rats

Our previous work has shown a synergistic tumoricidal action of the hexokinase (HK) inhibitor 2-deoxyglucose (2-DG) and the autophagy inhibitor chloroquine (CQ) on HK2-addicted prostate cancers in animal models through intraperitoneal injections. Here we developed high performance liquid chromatogra...

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Detalles Bibliográficos
Autores principales: Sun, Dongxiao, Kim, Sangyub, Karelia, Deepkamal, Deng, Yibin, Jiang, Cheng, Lü, Junxuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055671/
https://www.ncbi.nlm.nih.gov/pubmed/36993275
http://dx.doi.org/10.21203/rs.3.rs-2675386/v1