Immune niches in brain metastases contain TCF1+ stem-like T cells, are associated with disease control and are modulated by preoperative SRS

The CD8(+) T-cell response is prognostic for survival outcomes in several tumor types. However, whether this extends to tumors in the brain, an organ with barriers to T cell entry, remains unclear. Here, we analyzed immune infiltration in 67 brain metastasis (BrM) and found high frequencies of PD1(+...

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Detalles Bibliográficos
Autores principales: Jansen, Caroline S., Prabhu, Roshan S., Pagadala, Meghana S., Chappa, Prasanthi, Goyal, Subir, Zhou, Chengjing, Neill, Stewart G., Prokhnevska, Nataliya, Cardenas, Maria, Hoang, Kimberly B., Zhong, Jim, Torres, Mylin, Logan, Suzanna, Olson, Jeffrey J., Nduom, Edjah K., del Balzo, Luke, Patel, Kirtesh, Burri, Stuart H., Asher, Anthony L., Wilkinson, Scott, Lake, Ross, Higgins, Kristin A., Patel, Pretesh, Dhere, Vishal, Sowalsky, Adam G., Khan, Mohammad K., Kissick, Haydn, Buchwald, Zachary S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055679/
https://www.ncbi.nlm.nih.gov/pubmed/36993444
http://dx.doi.org/10.21203/rs.3.rs-2722744/v1

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