Dual Disseminated Aspergillosis and Mucormycosis Diagnosed at Autopsy: A Report of Two Cases of Coinfection and a Review of the Literature

Coinfection with invasive aspergillosis and mucormycosis in immunocompromised patients has been reported but is rarely confirmed by tissue histology or autopsy. Serum fungal biomarkers and culture are the primary diagnostic tools but are suboptimal for detecting fungal coinfection. Here, we present...

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Detalles Bibliográficos
Autores principales: Murray, Jason, Lu, Zhen A., Miller, Karin, Meadows, Alex, Totten, Marissa, Zhang, Sean X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055918/
https://www.ncbi.nlm.nih.gov/pubmed/36983525
http://dx.doi.org/10.3390/jof9030357
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author Murray, Jason
Lu, Zhen A.
Miller, Karin
Meadows, Alex
Totten, Marissa
Zhang, Sean X.
author_facet Murray, Jason
Lu, Zhen A.
Miller, Karin
Meadows, Alex
Totten, Marissa
Zhang, Sean X.
author_sort Murray, Jason
collection PubMed
description Coinfection with invasive aspergillosis and mucormycosis in immunocompromised patients has been reported but is rarely confirmed by tissue histology or autopsy. Serum fungal biomarkers and culture are the primary diagnostic tools but are suboptimal for detecting fungal coinfection. Here, we present the cases of two patients who were immunocompromised due to hematologic malignancy where disseminated aspergillosis and mucormycosis coinfection was only diagnosed upon autopsy despite extensive fungal diagnostic workup, and also review recent literature of such instances of coinfection.
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spelling pubmed-100559182023-03-30 Dual Disseminated Aspergillosis and Mucormycosis Diagnosed at Autopsy: A Report of Two Cases of Coinfection and a Review of the Literature Murray, Jason Lu, Zhen A. Miller, Karin Meadows, Alex Totten, Marissa Zhang, Sean X. J Fungi (Basel) Brief Report Coinfection with invasive aspergillosis and mucormycosis in immunocompromised patients has been reported but is rarely confirmed by tissue histology or autopsy. Serum fungal biomarkers and culture are the primary diagnostic tools but are suboptimal for detecting fungal coinfection. Here, we present the cases of two patients who were immunocompromised due to hematologic malignancy where disseminated aspergillosis and mucormycosis coinfection was only diagnosed upon autopsy despite extensive fungal diagnostic workup, and also review recent literature of such instances of coinfection. MDPI 2023-03-15 /pmc/articles/PMC10055918/ /pubmed/36983525 http://dx.doi.org/10.3390/jof9030357 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Murray, Jason
Lu, Zhen A.
Miller, Karin
Meadows, Alex
Totten, Marissa
Zhang, Sean X.
Dual Disseminated Aspergillosis and Mucormycosis Diagnosed at Autopsy: A Report of Two Cases of Coinfection and a Review of the Literature
title Dual Disseminated Aspergillosis and Mucormycosis Diagnosed at Autopsy: A Report of Two Cases of Coinfection and a Review of the Literature
title_full Dual Disseminated Aspergillosis and Mucormycosis Diagnosed at Autopsy: A Report of Two Cases of Coinfection and a Review of the Literature
title_fullStr Dual Disseminated Aspergillosis and Mucormycosis Diagnosed at Autopsy: A Report of Two Cases of Coinfection and a Review of the Literature
title_full_unstemmed Dual Disseminated Aspergillosis and Mucormycosis Diagnosed at Autopsy: A Report of Two Cases of Coinfection and a Review of the Literature
title_short Dual Disseminated Aspergillosis and Mucormycosis Diagnosed at Autopsy: A Report of Two Cases of Coinfection and a Review of the Literature
title_sort dual disseminated aspergillosis and mucormycosis diagnosed at autopsy: a report of two cases of coinfection and a review of the literature
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055918/
https://www.ncbi.nlm.nih.gov/pubmed/36983525
http://dx.doi.org/10.3390/jof9030357
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