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Cytotoxicity Evaluation of Unmodified Paddlewheel Dirhodium(II,II)-Acetate/-Formamidinate Complexes and Their Axially Modified Low-Valent Metallodendrimers
Two diphenyl formamidine ligands, four dirhodium(II,II) complexes, and three axially modified low-valent dirhodium(II,II) metallodendrimers were synthesized and evaluated as anticancer agents against the A2780, A2780cis, and OVCAR-3 human ovarian cancer cell lines. The dirhodium(II,II) complexes sho...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055960/ https://www.ncbi.nlm.nih.gov/pubmed/36985643 http://dx.doi.org/10.3390/molecules28062671 |
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author | de Doncker, Stephen Fischer-Fodor, Eva Vlad, Cătălin Ioan Achimas-Cadariu, Patriciu Smith, Gregory S. Ngubane, Siyabonga |
author_facet | de Doncker, Stephen Fischer-Fodor, Eva Vlad, Cătălin Ioan Achimas-Cadariu, Patriciu Smith, Gregory S. Ngubane, Siyabonga |
author_sort | de Doncker, Stephen |
collection | PubMed |
description | Two diphenyl formamidine ligands, four dirhodium(II,II) complexes, and three axially modified low-valent dirhodium(II,II) metallodendrimers were synthesized and evaluated as anticancer agents against the A2780, A2780cis, and OVCAR-3 human ovarian cancer cell lines. The dirhodium(II,II) complexes show moderate cytotoxic activity in the tested tumor cell lines, with acetate and methyl-substituted formamidinate compounds displaying increased cytotoxicity that is relative to cisplatin in the A2780cis cisplatin resistant cell line. Additionally, methyl- and fluoro-substituted formamidinate complexes showed comparable and increased cytotoxic activity in the OVCAR-3 cell line when compared to cisplatin. The low-valent metallodendrimers show some activity, but a general decrease in cytotoxicity was observed when compared to the precursor complexes in all but one case, which is where the more active acetate-derived metallodendrimer showed a lower IC(50) value in the OVCAR-3 cell line in comparison with the dirhodium(II,II) tetraacetate. |
format | Online Article Text |
id | pubmed-10055960 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100559602023-03-30 Cytotoxicity Evaluation of Unmodified Paddlewheel Dirhodium(II,II)-Acetate/-Formamidinate Complexes and Their Axially Modified Low-Valent Metallodendrimers de Doncker, Stephen Fischer-Fodor, Eva Vlad, Cătălin Ioan Achimas-Cadariu, Patriciu Smith, Gregory S. Ngubane, Siyabonga Molecules Article Two diphenyl formamidine ligands, four dirhodium(II,II) complexes, and three axially modified low-valent dirhodium(II,II) metallodendrimers were synthesized and evaluated as anticancer agents against the A2780, A2780cis, and OVCAR-3 human ovarian cancer cell lines. The dirhodium(II,II) complexes show moderate cytotoxic activity in the tested tumor cell lines, with acetate and methyl-substituted formamidinate compounds displaying increased cytotoxicity that is relative to cisplatin in the A2780cis cisplatin resistant cell line. Additionally, methyl- and fluoro-substituted formamidinate complexes showed comparable and increased cytotoxic activity in the OVCAR-3 cell line when compared to cisplatin. The low-valent metallodendrimers show some activity, but a general decrease in cytotoxicity was observed when compared to the precursor complexes in all but one case, which is where the more active acetate-derived metallodendrimer showed a lower IC(50) value in the OVCAR-3 cell line in comparison with the dirhodium(II,II) tetraacetate. MDPI 2023-03-15 /pmc/articles/PMC10055960/ /pubmed/36985643 http://dx.doi.org/10.3390/molecules28062671 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article de Doncker, Stephen Fischer-Fodor, Eva Vlad, Cătălin Ioan Achimas-Cadariu, Patriciu Smith, Gregory S. Ngubane, Siyabonga Cytotoxicity Evaluation of Unmodified Paddlewheel Dirhodium(II,II)-Acetate/-Formamidinate Complexes and Their Axially Modified Low-Valent Metallodendrimers |
title | Cytotoxicity Evaluation of Unmodified Paddlewheel Dirhodium(II,II)-Acetate/-Formamidinate Complexes and Their Axially Modified Low-Valent Metallodendrimers |
title_full | Cytotoxicity Evaluation of Unmodified Paddlewheel Dirhodium(II,II)-Acetate/-Formamidinate Complexes and Their Axially Modified Low-Valent Metallodendrimers |
title_fullStr | Cytotoxicity Evaluation of Unmodified Paddlewheel Dirhodium(II,II)-Acetate/-Formamidinate Complexes and Their Axially Modified Low-Valent Metallodendrimers |
title_full_unstemmed | Cytotoxicity Evaluation of Unmodified Paddlewheel Dirhodium(II,II)-Acetate/-Formamidinate Complexes and Their Axially Modified Low-Valent Metallodendrimers |
title_short | Cytotoxicity Evaluation of Unmodified Paddlewheel Dirhodium(II,II)-Acetate/-Formamidinate Complexes and Their Axially Modified Low-Valent Metallodendrimers |
title_sort | cytotoxicity evaluation of unmodified paddlewheel dirhodium(ii,ii)-acetate/-formamidinate complexes and their axially modified low-valent metallodendrimers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055960/ https://www.ncbi.nlm.nih.gov/pubmed/36985643 http://dx.doi.org/10.3390/molecules28062671 |
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