Botulinum Neurotoxin A4 Has a 1000-Fold Reduced Potency Due to Three Single Amino Acid Alterations in the Protein Receptor Binding Domain

Botulinum neurotoxin subtype A4 (BoNT/A4) is ~1000-fold less potent than BoNT/A1. This study addresses the basis for low BoNT/A4 potency. Utilizing BoNT/A1-A4 and BoNT/A4-A1 Light Chain-Heavy Chain (LC-HC) chimeras, HC-A4 was responsible for low BoNT/A4 potency. Earlier studies showed BoNT/A1-recept...

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Detalles Bibliográficos
Autores principales: Tepp, William H., Bradshaw, Marite, Gardner, Alexander P., Kaufman, Rebecca L., Barbieri, Joseph T., Pellett, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10055998/
https://www.ncbi.nlm.nih.gov/pubmed/36982762
http://dx.doi.org/10.3390/ijms24065690

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