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Virus Infection Impairs Fungal Response to Stress: Effect of Salt

Infection with Aspergillus fumigatus polymycovirus 1 (AfuPmV-1) weakens the resistance of biofilms of common A. fumigatus reference strain Af293 in intermicrobial competition with Pseudomonas aeruginosa, and sensitizes A. fumigatus for antifungal effects of nikkomycin Z. We compared the sensitivity...

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Autores principales: Stevens, David A., Kotta-Loizou, Ioly, Martinez, Marife, Coutts, Robert H. A., Sass, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056142/
https://www.ncbi.nlm.nih.gov/pubmed/36992427
http://dx.doi.org/10.3390/v15030718
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author Stevens, David A.
Kotta-Loizou, Ioly
Martinez, Marife
Coutts, Robert H. A.
Sass, Gabriele
author_facet Stevens, David A.
Kotta-Loizou, Ioly
Martinez, Marife
Coutts, Robert H. A.
Sass, Gabriele
author_sort Stevens, David A.
collection PubMed
description Infection with Aspergillus fumigatus polymycovirus 1 (AfuPmV-1) weakens the resistance of biofilms of common A. fumigatus reference strain Af293 in intermicrobial competition with Pseudomonas aeruginosa, and sensitizes A. fumigatus for antifungal effects of nikkomycin Z. We compared the sensitivity of two virus-infected (VI) and one virus-free (VF) Af293 strains to hypertonic salt. Salt stress impairs the growth of VI and VF at all times; VF control growth always exceeds VI, and VF growth in salt always exceeds VI. Since VF growth exceeds VI in the presence and absence of salt, we also examined growth in salt as a percentage of control growth. Initially, as a percentage of control, VI exceeded VF, but at 120 h VF began to exceed VI consistently even by this measure; thus, at that time the growth of VF in salt surges in relation to control growth, or, alternatively, its growth in salt persists compared to the relative inhibition of VI. In summary, virus infection impairs the response of A. fumigatus to several different stresses, including hypertonic salt.
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spelling pubmed-100561422023-03-30 Virus Infection Impairs Fungal Response to Stress: Effect of Salt Stevens, David A. Kotta-Loizou, Ioly Martinez, Marife Coutts, Robert H. A. Sass, Gabriele Viruses Communication Infection with Aspergillus fumigatus polymycovirus 1 (AfuPmV-1) weakens the resistance of biofilms of common A. fumigatus reference strain Af293 in intermicrobial competition with Pseudomonas aeruginosa, and sensitizes A. fumigatus for antifungal effects of nikkomycin Z. We compared the sensitivity of two virus-infected (VI) and one virus-free (VF) Af293 strains to hypertonic salt. Salt stress impairs the growth of VI and VF at all times; VF control growth always exceeds VI, and VF growth in salt always exceeds VI. Since VF growth exceeds VI in the presence and absence of salt, we also examined growth in salt as a percentage of control growth. Initially, as a percentage of control, VI exceeded VF, but at 120 h VF began to exceed VI consistently even by this measure; thus, at that time the growth of VF in salt surges in relation to control growth, or, alternatively, its growth in salt persists compared to the relative inhibition of VI. In summary, virus infection impairs the response of A. fumigatus to several different stresses, including hypertonic salt. MDPI 2023-03-10 /pmc/articles/PMC10056142/ /pubmed/36992427 http://dx.doi.org/10.3390/v15030718 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Stevens, David A.
Kotta-Loizou, Ioly
Martinez, Marife
Coutts, Robert H. A.
Sass, Gabriele
Virus Infection Impairs Fungal Response to Stress: Effect of Salt
title Virus Infection Impairs Fungal Response to Stress: Effect of Salt
title_full Virus Infection Impairs Fungal Response to Stress: Effect of Salt
title_fullStr Virus Infection Impairs Fungal Response to Stress: Effect of Salt
title_full_unstemmed Virus Infection Impairs Fungal Response to Stress: Effect of Salt
title_short Virus Infection Impairs Fungal Response to Stress: Effect of Salt
title_sort virus infection impairs fungal response to stress: effect of salt
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056142/
https://www.ncbi.nlm.nih.gov/pubmed/36992427
http://dx.doi.org/10.3390/v15030718
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