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Metastasis in Neuroblastoma and Its Link to Autophagy

Neuroblastoma is a paediatric malignancy originating from the neural crest that commonly occurs in the abdomen and adrenal gland, leading to cancer-related deaths in children. Distant metastasis can be encountered at diagnosis in greater than half of these neuroblastoma patients. Autophagy, a self-d...

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Detalles Bibliográficos
Autor principal: Jahangiri, Leila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056181/
https://www.ncbi.nlm.nih.gov/pubmed/36983973
http://dx.doi.org/10.3390/life13030818
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author Jahangiri, Leila
author_facet Jahangiri, Leila
author_sort Jahangiri, Leila
collection PubMed
description Neuroblastoma is a paediatric malignancy originating from the neural crest that commonly occurs in the abdomen and adrenal gland, leading to cancer-related deaths in children. Distant metastasis can be encountered at diagnosis in greater than half of these neuroblastoma patients. Autophagy, a self-degradative process, plays a key role in stress-related responses and the survival of cells and has been studied in neuroblastoma. Accordingly, in the early stages of metastasis, autophagy may suppress cancer cell invasion and migration, while its role may be reversed in later stages, and it may facilitate metastasis by enhancing cancer cell survival. To that end, a body of literature has revealed the mechanistic link between autophagy and metastasis in neuroblastoma in multiple steps of the metastatic cascade, including cancer cell invasion and migration, anoikis resistance, cancer cell dormancy, micrometastasis, and metastatic outbreak. This review aims to take a step forward and discuss the significance of multiple molecular players and compounds that may link autophagy to metastasis and map their function to various metastatic steps in neuroblastoma.
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spelling pubmed-100561812023-03-30 Metastasis in Neuroblastoma and Its Link to Autophagy Jahangiri, Leila Life (Basel) Review Neuroblastoma is a paediatric malignancy originating from the neural crest that commonly occurs in the abdomen and adrenal gland, leading to cancer-related deaths in children. Distant metastasis can be encountered at diagnosis in greater than half of these neuroblastoma patients. Autophagy, a self-degradative process, plays a key role in stress-related responses and the survival of cells and has been studied in neuroblastoma. Accordingly, in the early stages of metastasis, autophagy may suppress cancer cell invasion and migration, while its role may be reversed in later stages, and it may facilitate metastasis by enhancing cancer cell survival. To that end, a body of literature has revealed the mechanistic link between autophagy and metastasis in neuroblastoma in multiple steps of the metastatic cascade, including cancer cell invasion and migration, anoikis resistance, cancer cell dormancy, micrometastasis, and metastatic outbreak. This review aims to take a step forward and discuss the significance of multiple molecular players and compounds that may link autophagy to metastasis and map their function to various metastatic steps in neuroblastoma. MDPI 2023-03-17 /pmc/articles/PMC10056181/ /pubmed/36983973 http://dx.doi.org/10.3390/life13030818 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jahangiri, Leila
Metastasis in Neuroblastoma and Its Link to Autophagy
title Metastasis in Neuroblastoma and Its Link to Autophagy
title_full Metastasis in Neuroblastoma and Its Link to Autophagy
title_fullStr Metastasis in Neuroblastoma and Its Link to Autophagy
title_full_unstemmed Metastasis in Neuroblastoma and Its Link to Autophagy
title_short Metastasis in Neuroblastoma and Its Link to Autophagy
title_sort metastasis in neuroblastoma and its link to autophagy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056181/
https://www.ncbi.nlm.nih.gov/pubmed/36983973
http://dx.doi.org/10.3390/life13030818
work_keys_str_mv AT jahangirileila metastasisinneuroblastomaanditslinktoautophagy