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Roxadustat (FG-4592) abated lipopolysaccharides-induced depressive-like symptoms via PI3K signaling

BACKGROUND: Despite its role in inflammation and the redox system under hypoxia, the effects and molecular mechanisms of hypoxia-inducible factor (HIF) in neuroinflammation-associated depression are poorly explored. Furthermore, Prolyl hydroxylase domain-containing proteins (PHDs) regulate HIF-1; ho...

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Detalles Bibliográficos
Autores principales:	Li, Axiang, Liu, Zizhen, Ali, Tahir, Gao, Ruyan, Luo, Yanhua, Gong, Qichao, Zheng, Chenyou, Li, Weifen, Guo, Hongling, Liu, Xinshe, Li, Shupeng, Li, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Molecular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056220/ https://www.ncbi.nlm.nih.gov/pubmed/37008780 http://dx.doi.org/10.3389/fnmol.2023.1048985

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