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Therapeutic Vaccination in Head and Neck Squamous Cell Carcinoma—A Review

Therapeutic vaccination is one of the most effective immunotherapeutic approaches, second only to immune checkpoint inhibitors (ICIs), which have already been approved for clinical use. Head and neck squamous cell carcinomas (HNSCCs) are heterogenous epithelial tumors of the upper aerodigestive trac...

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Detalles Bibliográficos
Autores principales: Devaraja, K., Aggarwal, Sadhna, Singh, Manisha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056222/
https://www.ncbi.nlm.nih.gov/pubmed/36992219
http://dx.doi.org/10.3390/vaccines11030634
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author Devaraja, K.
Aggarwal, Sadhna
Singh, Manisha
author_facet Devaraja, K.
Aggarwal, Sadhna
Singh, Manisha
author_sort Devaraja, K.
collection PubMed
description Therapeutic vaccination is one of the most effective immunotherapeutic approaches, second only to immune checkpoint inhibitors (ICIs), which have already been approved for clinical use. Head and neck squamous cell carcinomas (HNSCCs) are heterogenous epithelial tumors of the upper aerodigestive tract, and a significant proportion of these tumors tend to exhibit unfavorable therapeutic responses to the existing treatment options. Comprehending the immunopathology of these tumors and choosing an appropriate immunotherapeutic maneuver seems to be a promising avenue for solving this problem. The current review provides a detailed overview of the strategies, targets, and candidates for therapeutic vaccination in HNSCC. The classical principle of inducing a potent, antigen-specific, cell-mediated cytotoxicity targeting a specific tumor antigen seems to be the most effective mechanism of therapeutic vaccination, particularly against the human papilloma virus positive subset of HNSCC. However, approaches such as countering the immunosuppressive tumor microenvironment of HNSCC and immune co-stimulatory mechanisms have also been explored recently, with encouraging results.
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spelling pubmed-100562222023-03-30 Therapeutic Vaccination in Head and Neck Squamous Cell Carcinoma—A Review Devaraja, K. Aggarwal, Sadhna Singh, Manisha Vaccines (Basel) Review Therapeutic vaccination is one of the most effective immunotherapeutic approaches, second only to immune checkpoint inhibitors (ICIs), which have already been approved for clinical use. Head and neck squamous cell carcinomas (HNSCCs) are heterogenous epithelial tumors of the upper aerodigestive tract, and a significant proportion of these tumors tend to exhibit unfavorable therapeutic responses to the existing treatment options. Comprehending the immunopathology of these tumors and choosing an appropriate immunotherapeutic maneuver seems to be a promising avenue for solving this problem. The current review provides a detailed overview of the strategies, targets, and candidates for therapeutic vaccination in HNSCC. The classical principle of inducing a potent, antigen-specific, cell-mediated cytotoxicity targeting a specific tumor antigen seems to be the most effective mechanism of therapeutic vaccination, particularly against the human papilloma virus positive subset of HNSCC. However, approaches such as countering the immunosuppressive tumor microenvironment of HNSCC and immune co-stimulatory mechanisms have also been explored recently, with encouraging results. MDPI 2023-03-13 /pmc/articles/PMC10056222/ /pubmed/36992219 http://dx.doi.org/10.3390/vaccines11030634 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Devaraja, K.
Aggarwal, Sadhna
Singh, Manisha
Therapeutic Vaccination in Head and Neck Squamous Cell Carcinoma—A Review
title Therapeutic Vaccination in Head and Neck Squamous Cell Carcinoma—A Review
title_full Therapeutic Vaccination in Head and Neck Squamous Cell Carcinoma—A Review
title_fullStr Therapeutic Vaccination in Head and Neck Squamous Cell Carcinoma—A Review
title_full_unstemmed Therapeutic Vaccination in Head and Neck Squamous Cell Carcinoma—A Review
title_short Therapeutic Vaccination in Head and Neck Squamous Cell Carcinoma—A Review
title_sort therapeutic vaccination in head and neck squamous cell carcinoma—a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056222/
https://www.ncbi.nlm.nih.gov/pubmed/36992219
http://dx.doi.org/10.3390/vaccines11030634
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