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Nucleotides Entrapped in Liposome Nanovesicles as Tools for Therapeutic and Diagnostic Use in Biomedical Applications

The use of nucleotides for biomedical applications is an old desire in the scientific community. As we will present here, there are references published over the past 40 years with this intended use. The main problem is that, as unstable molecules, nucleotides require some additional protection to e...

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Autores principales: Cardador, Camila Magalhães, Muehlmann, Luis Alexandre, Coelho, Cíntia Marques, Silva, Luciano Paulino, Garay, Aisel Valle, Carvalho, Alexandra Maria dos Santos, Bastos, Izabela Marques Dourado, Longo, João Paulo Figueiró
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056227/
https://www.ncbi.nlm.nih.gov/pubmed/36986734
http://dx.doi.org/10.3390/pharmaceutics15030873
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author Cardador, Camila Magalhães
Muehlmann, Luis Alexandre
Coelho, Cíntia Marques
Silva, Luciano Paulino
Garay, Aisel Valle
Carvalho, Alexandra Maria dos Santos
Bastos, Izabela Marques Dourado
Longo, João Paulo Figueiró
author_facet Cardador, Camila Magalhães
Muehlmann, Luis Alexandre
Coelho, Cíntia Marques
Silva, Luciano Paulino
Garay, Aisel Valle
Carvalho, Alexandra Maria dos Santos
Bastos, Izabela Marques Dourado
Longo, João Paulo Figueiró
author_sort Cardador, Camila Magalhães
collection PubMed
description The use of nucleotides for biomedical applications is an old desire in the scientific community. As we will present here, there are references published over the past 40 years with this intended use. The main problem is that, as unstable molecules, nucleotides require some additional protection to extend their shelf life in the biological environment. Among the different nucleotide carriers, the nano-sized liposomes proved to be an effective strategic tool to overcome all these drawbacks related to the nucleotide high instability. Moreover, due to their low immunogenicity and easy preparation, the liposomes were selected as the main strategy for delivery of the mRNA developed for COVID-19 immunization. For sure this is the most important and relevant example of nucleotide application for human biomedical conditions. In addition, the use of mRNA vaccines for COVID-19 has increased interest in the application of this type of technology to other health conditions. For this review article, we will present some of these examples, especially focused on the use of liposomes to protect and deliver nucleotides for cancer therapy, immunostimulatory activities, enzymatic diagnostic applications, some examples for veterinarian use, and the treatment of neglected tropical disease.
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spelling pubmed-100562272023-03-30 Nucleotides Entrapped in Liposome Nanovesicles as Tools for Therapeutic and Diagnostic Use in Biomedical Applications Cardador, Camila Magalhães Muehlmann, Luis Alexandre Coelho, Cíntia Marques Silva, Luciano Paulino Garay, Aisel Valle Carvalho, Alexandra Maria dos Santos Bastos, Izabela Marques Dourado Longo, João Paulo Figueiró Pharmaceutics Review The use of nucleotides for biomedical applications is an old desire in the scientific community. As we will present here, there are references published over the past 40 years with this intended use. The main problem is that, as unstable molecules, nucleotides require some additional protection to extend their shelf life in the biological environment. Among the different nucleotide carriers, the nano-sized liposomes proved to be an effective strategic tool to overcome all these drawbacks related to the nucleotide high instability. Moreover, due to their low immunogenicity and easy preparation, the liposomes were selected as the main strategy for delivery of the mRNA developed for COVID-19 immunization. For sure this is the most important and relevant example of nucleotide application for human biomedical conditions. In addition, the use of mRNA vaccines for COVID-19 has increased interest in the application of this type of technology to other health conditions. For this review article, we will present some of these examples, especially focused on the use of liposomes to protect and deliver nucleotides for cancer therapy, immunostimulatory activities, enzymatic diagnostic applications, some examples for veterinarian use, and the treatment of neglected tropical disease. MDPI 2023-03-08 /pmc/articles/PMC10056227/ /pubmed/36986734 http://dx.doi.org/10.3390/pharmaceutics15030873 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cardador, Camila Magalhães
Muehlmann, Luis Alexandre
Coelho, Cíntia Marques
Silva, Luciano Paulino
Garay, Aisel Valle
Carvalho, Alexandra Maria dos Santos
Bastos, Izabela Marques Dourado
Longo, João Paulo Figueiró
Nucleotides Entrapped in Liposome Nanovesicles as Tools for Therapeutic and Diagnostic Use in Biomedical Applications
title Nucleotides Entrapped in Liposome Nanovesicles as Tools for Therapeutic and Diagnostic Use in Biomedical Applications
title_full Nucleotides Entrapped in Liposome Nanovesicles as Tools for Therapeutic and Diagnostic Use in Biomedical Applications
title_fullStr Nucleotides Entrapped in Liposome Nanovesicles as Tools for Therapeutic and Diagnostic Use in Biomedical Applications
title_full_unstemmed Nucleotides Entrapped in Liposome Nanovesicles as Tools for Therapeutic and Diagnostic Use in Biomedical Applications
title_short Nucleotides Entrapped in Liposome Nanovesicles as Tools for Therapeutic and Diagnostic Use in Biomedical Applications
title_sort nucleotides entrapped in liposome nanovesicles as tools for therapeutic and diagnostic use in biomedical applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056227/
https://www.ncbi.nlm.nih.gov/pubmed/36986734
http://dx.doi.org/10.3390/pharmaceutics15030873
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