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Growth Velocity and Nutritional Status in Children Exposed to Zika Virus during Pregnancy from Amazonas Cohort, Brazil

The high incidence of Zika virus (ZIKV) infection in the period of 2015–2016 in Brazil may have affected linear height growth velocity (GV) in children exposed in utero to ZIKV. This study describes the growth velocity and nutritional status based on the World Organization (WHO) standards of childre...

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Detalles Bibliográficos
Autores principales: Peixoto, Lucíola de Fátima Albuquerque de Almeida, Abtibol-Bernardino, Marília Rosa, Guerra, Cecilia Victoria Caraballo, de Oliveira, Geruza Alfaia, Chaves, Beatriz Caroline Soares, de Souza Rodrigues, Cristina, de Andrade, Anny Beatriz Costa Antony, de Fátima Redivo, Elijane, Fernandes, Salete Sara Alvarez, Otani, Rodrigo Haruo, da Silva Neto, Alexandre Vilhena, da Silva Balieiro, Antônio Alcirley, Cabral, Celso Rômulo Barbosa, Baia-da-Silva, Djane, Castilho, Márcia da Costa, Bôtto-Menezes, Camila Helena, Alecrim, Maria das Graças Costa, Leal, Maria do Carmo, Benzecry, Silvana Gomes, Martinez-Espinosa, Flor Ernestina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056230/
https://www.ncbi.nlm.nih.gov/pubmed/36992371
http://dx.doi.org/10.3390/v15030662
Descripción
Sumario:The high incidence of Zika virus (ZIKV) infection in the period of 2015–2016 in Brazil may have affected linear height growth velocity (GV) in children exposed in utero to ZIKV. This study describes the growth velocity and nutritional status based on the World Organization (WHO) standards of children exposed to ZIKV during pregnancy and followed up in a tertiary unit, a reference for tropical and infectious diseases in the Amazon. Seventy-one children born between March 2016 and June 2018 were monitored for anthropometric indices: z-score for body mass index (BMI/A); weight (W/A); height (H/A) and head circumference (HC/A); and growth velocity. The mean age at the last assessment was 21.1 months (SD ± 8.93). Four children had congenital microcephaly and severe neurological impairment. The other 67 were non-microcephalic children (60 normocephalic and 7 macrocephalic); of these; 24.2% (16 children) had neurological alterations, and 28.8% (19 children) had altered neuropsychomotor development. Seventeen (24.2%) children had inadequate GV (low growth velocity). The frequencies of low growth among microcephalic and non-microcephalic patients are 25% (1 of 4 children) and 23.9% (16 of 67 children); respectively. Most children had normal BMI/A values during follow-up. Microcephalic patients showed low H/A and HC/A throughout the follow-up, with a significant reduction in the HC/A z-score. Non-microcephalic individuals are within the regular ranges for H/A; HC/A; and W/A, except for the H/A score for boys. This study showed low growth velocity in children with and without microcephaly, highlighting the need for continuous evaluation of all children born to mothers exposed to ZIKV during pregnancy.