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Growth Velocity and Nutritional Status in Children Exposed to Zika Virus during Pregnancy from Amazonas Cohort, Brazil

The high incidence of Zika virus (ZIKV) infection in the period of 2015–2016 in Brazil may have affected linear height growth velocity (GV) in children exposed in utero to ZIKV. This study describes the growth velocity and nutritional status based on the World Organization (WHO) standards of childre...

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Autores principales: Peixoto, Lucíola de Fátima Albuquerque de Almeida, Abtibol-Bernardino, Marília Rosa, Guerra, Cecilia Victoria Caraballo, de Oliveira, Geruza Alfaia, Chaves, Beatriz Caroline Soares, de Souza Rodrigues, Cristina, de Andrade, Anny Beatriz Costa Antony, de Fátima Redivo, Elijane, Fernandes, Salete Sara Alvarez, Otani, Rodrigo Haruo, da Silva Neto, Alexandre Vilhena, da Silva Balieiro, Antônio Alcirley, Cabral, Celso Rômulo Barbosa, Baia-da-Silva, Djane, Castilho, Márcia da Costa, Bôtto-Menezes, Camila Helena, Alecrim, Maria das Graças Costa, Leal, Maria do Carmo, Benzecry, Silvana Gomes, Martinez-Espinosa, Flor Ernestina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056230/
https://www.ncbi.nlm.nih.gov/pubmed/36992371
http://dx.doi.org/10.3390/v15030662
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author Peixoto, Lucíola de Fátima Albuquerque de Almeida
Abtibol-Bernardino, Marília Rosa
Guerra, Cecilia Victoria Caraballo
de Oliveira, Geruza Alfaia
Chaves, Beatriz Caroline Soares
de Souza Rodrigues, Cristina
de Andrade, Anny Beatriz Costa Antony
de Fátima Redivo, Elijane
Fernandes, Salete Sara Alvarez
Otani, Rodrigo Haruo
da Silva Neto, Alexandre Vilhena
da Silva Balieiro, Antônio Alcirley
Cabral, Celso Rômulo Barbosa
Baia-da-Silva, Djane
Castilho, Márcia da Costa
Bôtto-Menezes, Camila Helena
Alecrim, Maria das Graças Costa
Leal, Maria do Carmo
Benzecry, Silvana Gomes
Martinez-Espinosa, Flor Ernestina
author_facet Peixoto, Lucíola de Fátima Albuquerque de Almeida
Abtibol-Bernardino, Marília Rosa
Guerra, Cecilia Victoria Caraballo
de Oliveira, Geruza Alfaia
Chaves, Beatriz Caroline Soares
de Souza Rodrigues, Cristina
de Andrade, Anny Beatriz Costa Antony
de Fátima Redivo, Elijane
Fernandes, Salete Sara Alvarez
Otani, Rodrigo Haruo
da Silva Neto, Alexandre Vilhena
da Silva Balieiro, Antônio Alcirley
Cabral, Celso Rômulo Barbosa
Baia-da-Silva, Djane
Castilho, Márcia da Costa
Bôtto-Menezes, Camila Helena
Alecrim, Maria das Graças Costa
Leal, Maria do Carmo
Benzecry, Silvana Gomes
Martinez-Espinosa, Flor Ernestina
author_sort Peixoto, Lucíola de Fátima Albuquerque de Almeida
collection PubMed
description The high incidence of Zika virus (ZIKV) infection in the period of 2015–2016 in Brazil may have affected linear height growth velocity (GV) in children exposed in utero to ZIKV. This study describes the growth velocity and nutritional status based on the World Organization (WHO) standards of children exposed to ZIKV during pregnancy and followed up in a tertiary unit, a reference for tropical and infectious diseases in the Amazon. Seventy-one children born between March 2016 and June 2018 were monitored for anthropometric indices: z-score for body mass index (BMI/A); weight (W/A); height (H/A) and head circumference (HC/A); and growth velocity. The mean age at the last assessment was 21.1 months (SD ± 8.93). Four children had congenital microcephaly and severe neurological impairment. The other 67 were non-microcephalic children (60 normocephalic and 7 macrocephalic); of these; 24.2% (16 children) had neurological alterations, and 28.8% (19 children) had altered neuropsychomotor development. Seventeen (24.2%) children had inadequate GV (low growth velocity). The frequencies of low growth among microcephalic and non-microcephalic patients are 25% (1 of 4 children) and 23.9% (16 of 67 children); respectively. Most children had normal BMI/A values during follow-up. Microcephalic patients showed low H/A and HC/A throughout the follow-up, with a significant reduction in the HC/A z-score. Non-microcephalic individuals are within the regular ranges for H/A; HC/A; and W/A, except for the H/A score for boys. This study showed low growth velocity in children with and without microcephaly, highlighting the need for continuous evaluation of all children born to mothers exposed to ZIKV during pregnancy.
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spelling pubmed-100562302023-03-30 Growth Velocity and Nutritional Status in Children Exposed to Zika Virus during Pregnancy from Amazonas Cohort, Brazil Peixoto, Lucíola de Fátima Albuquerque de Almeida Abtibol-Bernardino, Marília Rosa Guerra, Cecilia Victoria Caraballo de Oliveira, Geruza Alfaia Chaves, Beatriz Caroline Soares de Souza Rodrigues, Cristina de Andrade, Anny Beatriz Costa Antony de Fátima Redivo, Elijane Fernandes, Salete Sara Alvarez Otani, Rodrigo Haruo da Silva Neto, Alexandre Vilhena da Silva Balieiro, Antônio Alcirley Cabral, Celso Rômulo Barbosa Baia-da-Silva, Djane Castilho, Márcia da Costa Bôtto-Menezes, Camila Helena Alecrim, Maria das Graças Costa Leal, Maria do Carmo Benzecry, Silvana Gomes Martinez-Espinosa, Flor Ernestina Viruses Article The high incidence of Zika virus (ZIKV) infection in the period of 2015–2016 in Brazil may have affected linear height growth velocity (GV) in children exposed in utero to ZIKV. This study describes the growth velocity and nutritional status based on the World Organization (WHO) standards of children exposed to ZIKV during pregnancy and followed up in a tertiary unit, a reference for tropical and infectious diseases in the Amazon. Seventy-one children born between March 2016 and June 2018 were monitored for anthropometric indices: z-score for body mass index (BMI/A); weight (W/A); height (H/A) and head circumference (HC/A); and growth velocity. The mean age at the last assessment was 21.1 months (SD ± 8.93). Four children had congenital microcephaly and severe neurological impairment. The other 67 were non-microcephalic children (60 normocephalic and 7 macrocephalic); of these; 24.2% (16 children) had neurological alterations, and 28.8% (19 children) had altered neuropsychomotor development. Seventeen (24.2%) children had inadequate GV (low growth velocity). The frequencies of low growth among microcephalic and non-microcephalic patients are 25% (1 of 4 children) and 23.9% (16 of 67 children); respectively. Most children had normal BMI/A values during follow-up. Microcephalic patients showed low H/A and HC/A throughout the follow-up, with a significant reduction in the HC/A z-score. Non-microcephalic individuals are within the regular ranges for H/A; HC/A; and W/A, except for the H/A score for boys. This study showed low growth velocity in children with and without microcephaly, highlighting the need for continuous evaluation of all children born to mothers exposed to ZIKV during pregnancy. MDPI 2023-03-01 /pmc/articles/PMC10056230/ /pubmed/36992371 http://dx.doi.org/10.3390/v15030662 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Peixoto, Lucíola de Fátima Albuquerque de Almeida
Abtibol-Bernardino, Marília Rosa
Guerra, Cecilia Victoria Caraballo
de Oliveira, Geruza Alfaia
Chaves, Beatriz Caroline Soares
de Souza Rodrigues, Cristina
de Andrade, Anny Beatriz Costa Antony
de Fátima Redivo, Elijane
Fernandes, Salete Sara Alvarez
Otani, Rodrigo Haruo
da Silva Neto, Alexandre Vilhena
da Silva Balieiro, Antônio Alcirley
Cabral, Celso Rômulo Barbosa
Baia-da-Silva, Djane
Castilho, Márcia da Costa
Bôtto-Menezes, Camila Helena
Alecrim, Maria das Graças Costa
Leal, Maria do Carmo
Benzecry, Silvana Gomes
Martinez-Espinosa, Flor Ernestina
Growth Velocity and Nutritional Status in Children Exposed to Zika Virus during Pregnancy from Amazonas Cohort, Brazil
title Growth Velocity and Nutritional Status in Children Exposed to Zika Virus during Pregnancy from Amazonas Cohort, Brazil
title_full Growth Velocity and Nutritional Status in Children Exposed to Zika Virus during Pregnancy from Amazonas Cohort, Brazil
title_fullStr Growth Velocity and Nutritional Status in Children Exposed to Zika Virus during Pregnancy from Amazonas Cohort, Brazil
title_full_unstemmed Growth Velocity and Nutritional Status in Children Exposed to Zika Virus during Pregnancy from Amazonas Cohort, Brazil
title_short Growth Velocity and Nutritional Status in Children Exposed to Zika Virus during Pregnancy from Amazonas Cohort, Brazil
title_sort growth velocity and nutritional status in children exposed to zika virus during pregnancy from amazonas cohort, brazil
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056230/
https://www.ncbi.nlm.nih.gov/pubmed/36992371
http://dx.doi.org/10.3390/v15030662
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