Origin of Elevated S-Glutathionylated GAPDH in Chronic Neurodegenerative Diseases

H(2)O(2)-oxidized glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalytic cysteine residues (C(c)(SH) undergo rapid S-glutathionylation. Restoration of the enzyme activity is accomplished by thiol/disulfide S(N)2 displacement (directly or enzymatically) forming glutathione disulfide (G(SS)G) and...

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Detalles Bibliográficos
Autores principales: Hyslop, Paul A., Boggs, Leonard N., Chaney, Michael O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056234/
https://www.ncbi.nlm.nih.gov/pubmed/36982600
http://dx.doi.org/10.3390/ijms24065529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056234/
https://www.ncbi.nlm.nih.gov/pubmed/36982600
http://dx.doi.org/10.3390/ijms24065529

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