Cargando…
Origin of Elevated S-Glutathionylated GAPDH in Chronic Neurodegenerative Diseases
H(2)O(2)-oxidized glyceraldehyde-3-phosphate dehydrogenase (GAPDH) catalytic cysteine residues (C(c)(SH) undergo rapid S-glutathionylation. Restoration of the enzyme activity is accomplished by thiol/disulfide S(N)2 displacement (directly or enzymatically) forming glutathione disulfide (G(SS)G) and...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056234/ https://www.ncbi.nlm.nih.gov/pubmed/36982600 http://dx.doi.org/10.3390/ijms24065529 |