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Potential Role of Vaginal Microbiota in Ovarian Cancer Carcinogenesis, Progression and Treatment

Ovarian cancer represents one of the most challenging gynecologic cancers which still has numerous unknowns on the underlying pathogenesis. In addition to the verified contributors such as genomic predisposition and medical history in the carcinogenesis, emerging evidence points out the potential ro...

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Detalles Bibliográficos
Autores principales: Zhao, Xiumiao, Liu, Zhaoxia, Chen, Tingtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056320/
https://www.ncbi.nlm.nih.gov/pubmed/36986809
http://dx.doi.org/10.3390/pharmaceutics15030948
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author Zhao, Xiumiao
Liu, Zhaoxia
Chen, Tingtao
author_facet Zhao, Xiumiao
Liu, Zhaoxia
Chen, Tingtao
author_sort Zhao, Xiumiao
collection PubMed
description Ovarian cancer represents one of the most challenging gynecologic cancers which still has numerous unknowns on the underlying pathogenesis. In addition to the verified contributors such as genomic predisposition and medical history in the carcinogenesis, emerging evidence points out the potential role of vaginal microbiota in ovarian cancer. Recent studies have underlined the presence of vaginal microbial dysbiosis in cancer cases. Increasing research also indicates the potential correlations between vaginal microbes and cancer carcinogenesis, progression and treatment. Currently, compared with other gynecologic cancers, reports on the roles of vaginal microbiota in ovarian cancer remain scarce and fragmentary. Therefore, in this review, we summarize the roles of vaginal microbiota in various gynecologic diseases, particularly focusing on the potential mechanisms and possible applications of vaginal microbiota in ovarian cancer, giving insight into the involvement of vaginal microbiota in gynecologic cancer treatment.
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spelling pubmed-100563202023-03-30 Potential Role of Vaginal Microbiota in Ovarian Cancer Carcinogenesis, Progression and Treatment Zhao, Xiumiao Liu, Zhaoxia Chen, Tingtao Pharmaceutics Review Ovarian cancer represents one of the most challenging gynecologic cancers which still has numerous unknowns on the underlying pathogenesis. In addition to the verified contributors such as genomic predisposition and medical history in the carcinogenesis, emerging evidence points out the potential role of vaginal microbiota in ovarian cancer. Recent studies have underlined the presence of vaginal microbial dysbiosis in cancer cases. Increasing research also indicates the potential correlations between vaginal microbes and cancer carcinogenesis, progression and treatment. Currently, compared with other gynecologic cancers, reports on the roles of vaginal microbiota in ovarian cancer remain scarce and fragmentary. Therefore, in this review, we summarize the roles of vaginal microbiota in various gynecologic diseases, particularly focusing on the potential mechanisms and possible applications of vaginal microbiota in ovarian cancer, giving insight into the involvement of vaginal microbiota in gynecologic cancer treatment. MDPI 2023-03-15 /pmc/articles/PMC10056320/ /pubmed/36986809 http://dx.doi.org/10.3390/pharmaceutics15030948 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhao, Xiumiao
Liu, Zhaoxia
Chen, Tingtao
Potential Role of Vaginal Microbiota in Ovarian Cancer Carcinogenesis, Progression and Treatment
title Potential Role of Vaginal Microbiota in Ovarian Cancer Carcinogenesis, Progression and Treatment
title_full Potential Role of Vaginal Microbiota in Ovarian Cancer Carcinogenesis, Progression and Treatment
title_fullStr Potential Role of Vaginal Microbiota in Ovarian Cancer Carcinogenesis, Progression and Treatment
title_full_unstemmed Potential Role of Vaginal Microbiota in Ovarian Cancer Carcinogenesis, Progression and Treatment
title_short Potential Role of Vaginal Microbiota in Ovarian Cancer Carcinogenesis, Progression and Treatment
title_sort potential role of vaginal microbiota in ovarian cancer carcinogenesis, progression and treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056320/
https://www.ncbi.nlm.nih.gov/pubmed/36986809
http://dx.doi.org/10.3390/pharmaceutics15030948
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