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Raman Spectroscopy for Early Detection of Cervical Cancer, a Global Women’s Health Issue—A Review

This review focuses on recent advances and future perspectives in the use of Raman spectroscopy for cervical cancer, a global women’s health issue. Cervical cancer is the fourth most common women’s cancer in the world, and unfortunately mainly affects younger women. However, when detected at the ear...

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Detalles Bibliográficos
Autores principales: Shaikh, Rubina, Daniel, Amuthachelvi, Lyng, Fiona M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056388/
https://www.ncbi.nlm.nih.gov/pubmed/36985474
http://dx.doi.org/10.3390/molecules28062502
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author Shaikh, Rubina
Daniel, Amuthachelvi
Lyng, Fiona M.
author_facet Shaikh, Rubina
Daniel, Amuthachelvi
Lyng, Fiona M.
author_sort Shaikh, Rubina
collection PubMed
description This review focuses on recent advances and future perspectives in the use of Raman spectroscopy for cervical cancer, a global women’s health issue. Cervical cancer is the fourth most common women’s cancer in the world, and unfortunately mainly affects younger women. However, when detected at the early precancer stage, it is highly treatable. High-quality cervical screening programmes and the introduction of the human papillomavirus (HPV) vaccine are reducing the incidence of cervical cancer in many countries, but screening is still essential for all women. Current gold standard methods include HPV testing and cytology for screening, followed by colposcopy and histopathology for diagnosis. However, these methods are limited in terms of sensitivity/specificity, cost, and time. New methods are required to aid clinicians in the early detection of cervical precancer. Over the past 20 years, the potential of Raman spectroscopy together with multivariate statistical analysis has been shown for the detection of cervical cancer. This review discusses the research to date on Raman spectroscopic approaches for cervical cancer using exfoliated cells, biofluid samples, and tissue ex vivo and in vivo.
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spelling pubmed-100563882023-03-30 Raman Spectroscopy for Early Detection of Cervical Cancer, a Global Women’s Health Issue—A Review Shaikh, Rubina Daniel, Amuthachelvi Lyng, Fiona M. Molecules Review This review focuses on recent advances and future perspectives in the use of Raman spectroscopy for cervical cancer, a global women’s health issue. Cervical cancer is the fourth most common women’s cancer in the world, and unfortunately mainly affects younger women. However, when detected at the early precancer stage, it is highly treatable. High-quality cervical screening programmes and the introduction of the human papillomavirus (HPV) vaccine are reducing the incidence of cervical cancer in many countries, but screening is still essential for all women. Current gold standard methods include HPV testing and cytology for screening, followed by colposcopy and histopathology for diagnosis. However, these methods are limited in terms of sensitivity/specificity, cost, and time. New methods are required to aid clinicians in the early detection of cervical precancer. Over the past 20 years, the potential of Raman spectroscopy together with multivariate statistical analysis has been shown for the detection of cervical cancer. This review discusses the research to date on Raman spectroscopic approaches for cervical cancer using exfoliated cells, biofluid samples, and tissue ex vivo and in vivo. MDPI 2023-03-09 /pmc/articles/PMC10056388/ /pubmed/36985474 http://dx.doi.org/10.3390/molecules28062502 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shaikh, Rubina
Daniel, Amuthachelvi
Lyng, Fiona M.
Raman Spectroscopy for Early Detection of Cervical Cancer, a Global Women’s Health Issue—A Review
title Raman Spectroscopy for Early Detection of Cervical Cancer, a Global Women’s Health Issue—A Review
title_full Raman Spectroscopy for Early Detection of Cervical Cancer, a Global Women’s Health Issue—A Review
title_fullStr Raman Spectroscopy for Early Detection of Cervical Cancer, a Global Women’s Health Issue—A Review
title_full_unstemmed Raman Spectroscopy for Early Detection of Cervical Cancer, a Global Women’s Health Issue—A Review
title_short Raman Spectroscopy for Early Detection of Cervical Cancer, a Global Women’s Health Issue—A Review
title_sort raman spectroscopy for early detection of cervical cancer, a global women’s health issue—a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056388/
https://www.ncbi.nlm.nih.gov/pubmed/36985474
http://dx.doi.org/10.3390/molecules28062502
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