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Role of Polyanions and Surfactant Head Group in the Formation of Polymer–Colloid Nanocontainers
Objectives. This study was aimed at the investigation of the supramolecular systems based on cationic surfactants bearing cyclic head groups (imidazolium and pyrrolidinium) and polyanions (polyacrylic acid (PAA) and human serum albumin (HSA)), and factors governing their structural behavior to creat...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056398/ https://www.ncbi.nlm.nih.gov/pubmed/36985966 http://dx.doi.org/10.3390/nano13061072 |
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author | Vasilieva, Elmira A. Kuznetsova, Darya A. Valeeva, Farida G. Kuznetsov, Denis M. Zakharova, Lucia Ya. |
author_facet | Vasilieva, Elmira A. Kuznetsova, Darya A. Valeeva, Farida G. Kuznetsov, Denis M. Zakharova, Lucia Ya. |
author_sort | Vasilieva, Elmira A. |
collection | PubMed |
description | Objectives. This study was aimed at the investigation of the supramolecular systems based on cationic surfactants bearing cyclic head groups (imidazolium and pyrrolidinium) and polyanions (polyacrylic acid (PAA) and human serum albumin (HSA)), and factors governing their structural behavior to create functional nanosystems with controlled properties. Research hypothesis. Mixed surfactant–PE complexes based on oppositely charged species are characterized by multifactor behavior strongly affected by the nature of both components. It was expected that the transition from a single surfactant solution to an admixture with PE might provide synergetic effects on structural characteristics and functional activity. To test this assumption, the concentration thresholds of aggregation, dimensional and charge characteristics, and solubilization capacity of amphiphiles in the presence of PEs have been determined by tensiometry, fluorescence and UV-visible spectroscopy, and dynamic/electrophoretic light scattering. Results. The formation of mixed surfactant–PAA aggregates with a hydrodynamic diameter of up to 190 nm has been shown. Polyanion additives led to a decrease in the critical micelle concentration of surfactants by two orders of magnitude (from 1 mM to 0.01 mM). A gradual increase in the zeta potential of HSA–surfactant systems from negative to positive value indicates that the electrostatic mechanism contributes to the binding of components. Additionally, 3D and conventional fluorescence spectroscopy showed that imidazolium surfactant had little effect on HSA conformation, and component binding occurs due to hydrogen bonding and Van der Waals interactions through the tryptophan amino acid residue of the protein. Surfactant–polyanion nanostructures improve the solubility of lipophilic medicines such as Warfarin, Amphotericin B, and Meloxicam. Perspectives. Surfactant–PE composition demonstrated beneficial solubilization activity and can be recommended for the construction of nanocontainers for hydrophobic drugs, with their efficacy tuned by the variation in surfactant head group and the nature of polyanions. |
format | Online Article Text |
id | pubmed-10056398 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100563982023-03-30 Role of Polyanions and Surfactant Head Group in the Formation of Polymer–Colloid Nanocontainers Vasilieva, Elmira A. Kuznetsova, Darya A. Valeeva, Farida G. Kuznetsov, Denis M. Zakharova, Lucia Ya. Nanomaterials (Basel) Article Objectives. This study was aimed at the investigation of the supramolecular systems based on cationic surfactants bearing cyclic head groups (imidazolium and pyrrolidinium) and polyanions (polyacrylic acid (PAA) and human serum albumin (HSA)), and factors governing their structural behavior to create functional nanosystems with controlled properties. Research hypothesis. Mixed surfactant–PE complexes based on oppositely charged species are characterized by multifactor behavior strongly affected by the nature of both components. It was expected that the transition from a single surfactant solution to an admixture with PE might provide synergetic effects on structural characteristics and functional activity. To test this assumption, the concentration thresholds of aggregation, dimensional and charge characteristics, and solubilization capacity of amphiphiles in the presence of PEs have been determined by tensiometry, fluorescence and UV-visible spectroscopy, and dynamic/electrophoretic light scattering. Results. The formation of mixed surfactant–PAA aggregates with a hydrodynamic diameter of up to 190 nm has been shown. Polyanion additives led to a decrease in the critical micelle concentration of surfactants by two orders of magnitude (from 1 mM to 0.01 mM). A gradual increase in the zeta potential of HSA–surfactant systems from negative to positive value indicates that the electrostatic mechanism contributes to the binding of components. Additionally, 3D and conventional fluorescence spectroscopy showed that imidazolium surfactant had little effect on HSA conformation, and component binding occurs due to hydrogen bonding and Van der Waals interactions through the tryptophan amino acid residue of the protein. Surfactant–polyanion nanostructures improve the solubility of lipophilic medicines such as Warfarin, Amphotericin B, and Meloxicam. Perspectives. Surfactant–PE composition demonstrated beneficial solubilization activity and can be recommended for the construction of nanocontainers for hydrophobic drugs, with their efficacy tuned by the variation in surfactant head group and the nature of polyanions. MDPI 2023-03-16 /pmc/articles/PMC10056398/ /pubmed/36985966 http://dx.doi.org/10.3390/nano13061072 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Vasilieva, Elmira A. Kuznetsova, Darya A. Valeeva, Farida G. Kuznetsov, Denis M. Zakharova, Lucia Ya. Role of Polyanions and Surfactant Head Group in the Formation of Polymer–Colloid Nanocontainers |
title | Role of Polyanions and Surfactant Head Group in the Formation of Polymer–Colloid Nanocontainers |
title_full | Role of Polyanions and Surfactant Head Group in the Formation of Polymer–Colloid Nanocontainers |
title_fullStr | Role of Polyanions and Surfactant Head Group in the Formation of Polymer–Colloid Nanocontainers |
title_full_unstemmed | Role of Polyanions and Surfactant Head Group in the Formation of Polymer–Colloid Nanocontainers |
title_short | Role of Polyanions and Surfactant Head Group in the Formation of Polymer–Colloid Nanocontainers |
title_sort | role of polyanions and surfactant head group in the formation of polymer–colloid nanocontainers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056398/ https://www.ncbi.nlm.nih.gov/pubmed/36985966 http://dx.doi.org/10.3390/nano13061072 |
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