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Controlling the Impact of Helicobacter pylori-Related Hyperhomocysteinemia on Neurodegeneration

Helicobacter pylori infection consists a high global burden affecting more than 50% of the world’s population. It is implicated, beyond substantiated local gastric pathologies, i.e., peptic ulcers and gastric cancer, in the pathophysiology of several neurodegenerative disorders, mainly by inducing h...

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Autores principales: Kountouras, Jannis, Doulberis, Michael, Papaefthymiou, Apostolis, Polyzos, Stergios A., Zavos, Christos, Kazakos, Evangelos, Arapoglou, Stergios, Kyrailidi, Foteini, Mouratidou, Maria C., Boziki, Marina, Vardaka, Elisabeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056452/
https://www.ncbi.nlm.nih.gov/pubmed/36984505
http://dx.doi.org/10.3390/medicina59030504
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author Kountouras, Jannis
Doulberis, Michael
Papaefthymiou, Apostolis
Polyzos, Stergios A.
Zavos, Christos
Kazakos, Evangelos
Arapoglou, Stergios
Kyrailidi, Foteini
Mouratidou, Maria C.
Boziki, Marina
Vardaka, Elisabeth
author_facet Kountouras, Jannis
Doulberis, Michael
Papaefthymiou, Apostolis
Polyzos, Stergios A.
Zavos, Christos
Kazakos, Evangelos
Arapoglou, Stergios
Kyrailidi, Foteini
Mouratidou, Maria C.
Boziki, Marina
Vardaka, Elisabeth
author_sort Kountouras, Jannis
collection PubMed
description Helicobacter pylori infection consists a high global burden affecting more than 50% of the world’s population. It is implicated, beyond substantiated local gastric pathologies, i.e., peptic ulcers and gastric cancer, in the pathophysiology of several neurodegenerative disorders, mainly by inducing hyperhomocysteinemia-related brain cortical thinning (BCT). BCT has been advocated as a possible biomarker associated with neurodegenerative central nervous system disorders such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and/or glaucoma, termed as “ocular Alzheimer’s disease”. According to the infection hypothesis in relation to neurodegeneration, Helicobacter pylori as non-commensal gut microbiome has been advocated as trigger and/or mediator of neurodegenerative diseases, such as the development of Alzheimer’s disease. Among others, Helicobacter pylori-related inflammatory mediators, defensins, autophagy, vitamin D, dietary factors, role of probiotics, and some pathogenetic considerations including relevant involved genes are discussed within this opinion article. In conclusion, by controlling the impact of Helicobacter pylori-related hyperhomocysteinemia on neurodegenerative disorders might offer benefits, and additional research is warranted to clarify this crucial topic currently representing a major worldwide burden.
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spelling pubmed-100564522023-03-30 Controlling the Impact of Helicobacter pylori-Related Hyperhomocysteinemia on Neurodegeneration Kountouras, Jannis Doulberis, Michael Papaefthymiou, Apostolis Polyzos, Stergios A. Zavos, Christos Kazakos, Evangelos Arapoglou, Stergios Kyrailidi, Foteini Mouratidou, Maria C. Boziki, Marina Vardaka, Elisabeth Medicina (Kaunas) Opinion Helicobacter pylori infection consists a high global burden affecting more than 50% of the world’s population. It is implicated, beyond substantiated local gastric pathologies, i.e., peptic ulcers and gastric cancer, in the pathophysiology of several neurodegenerative disorders, mainly by inducing hyperhomocysteinemia-related brain cortical thinning (BCT). BCT has been advocated as a possible biomarker associated with neurodegenerative central nervous system disorders such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and/or glaucoma, termed as “ocular Alzheimer’s disease”. According to the infection hypothesis in relation to neurodegeneration, Helicobacter pylori as non-commensal gut microbiome has been advocated as trigger and/or mediator of neurodegenerative diseases, such as the development of Alzheimer’s disease. Among others, Helicobacter pylori-related inflammatory mediators, defensins, autophagy, vitamin D, dietary factors, role of probiotics, and some pathogenetic considerations including relevant involved genes are discussed within this opinion article. In conclusion, by controlling the impact of Helicobacter pylori-related hyperhomocysteinemia on neurodegenerative disorders might offer benefits, and additional research is warranted to clarify this crucial topic currently representing a major worldwide burden. MDPI 2023-03-04 /pmc/articles/PMC10056452/ /pubmed/36984505 http://dx.doi.org/10.3390/medicina59030504 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Opinion
Kountouras, Jannis
Doulberis, Michael
Papaefthymiou, Apostolis
Polyzos, Stergios A.
Zavos, Christos
Kazakos, Evangelos
Arapoglou, Stergios
Kyrailidi, Foteini
Mouratidou, Maria C.
Boziki, Marina
Vardaka, Elisabeth
Controlling the Impact of Helicobacter pylori-Related Hyperhomocysteinemia on Neurodegeneration
title Controlling the Impact of Helicobacter pylori-Related Hyperhomocysteinemia on Neurodegeneration
title_full Controlling the Impact of Helicobacter pylori-Related Hyperhomocysteinemia on Neurodegeneration
title_fullStr Controlling the Impact of Helicobacter pylori-Related Hyperhomocysteinemia on Neurodegeneration
title_full_unstemmed Controlling the Impact of Helicobacter pylori-Related Hyperhomocysteinemia on Neurodegeneration
title_short Controlling the Impact of Helicobacter pylori-Related Hyperhomocysteinemia on Neurodegeneration
title_sort controlling the impact of helicobacter pylori-related hyperhomocysteinemia on neurodegeneration
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056452/
https://www.ncbi.nlm.nih.gov/pubmed/36984505
http://dx.doi.org/10.3390/medicina59030504
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