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Retinal Ischaemia in Diabetic Retinopathy: Understanding and Overcoming a Therapeutic Challenge
Background: Retinal ischaemia is present to a greater or lesser extent in all eyes with diabetic retinopathy (DR). Nonetheless, our understanding of its pathogenic mechanisms, risk factors, as well as other characteristics of retinal ischaemia in DR is very limited. To date, there is no treatment to...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056455/ https://www.ncbi.nlm.nih.gov/pubmed/36983406 http://dx.doi.org/10.3390/jcm12062406 |
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author | Mohite, Ajay A. Perais, Jennifer A. McCullough, Philip Lois, Noemi |
author_facet | Mohite, Ajay A. Perais, Jennifer A. McCullough, Philip Lois, Noemi |
author_sort | Mohite, Ajay A. |
collection | PubMed |
description | Background: Retinal ischaemia is present to a greater or lesser extent in all eyes with diabetic retinopathy (DR). Nonetheless, our understanding of its pathogenic mechanisms, risk factors, as well as other characteristics of retinal ischaemia in DR is very limited. To date, there is no treatment to revascularise ischaemic retina. Methods: Review of the literature highlighting the current knowledge on the topic of retinal ischaemia in DR, important observations made, and underlying gaps for which research is needed. Results: A very scarce number of clinical studies, mostly cross-sectional, have evaluated specifically retinal ischaemia in DR. Interindividual variability on its natural course and consequences, including the development of its major complications, namely diabetic macular ischaemia and proliferative diabetic retinopathy, have not been investigated. The in situ, surrounding, and distance effect of retinal ischaemia on retinal function and structure and its change over time remains also to be elucidated. Treatments to prevent the development of retinal ischaemia and, importantly, to achieve retinal reperfusion once capillary drop out has ensued, are very much needed and remain to be developed. Conclusion: Research into retinal ischaemia in diabetes should be a priority to save sight. |
format | Online Article Text |
id | pubmed-10056455 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100564552023-03-30 Retinal Ischaemia in Diabetic Retinopathy: Understanding and Overcoming a Therapeutic Challenge Mohite, Ajay A. Perais, Jennifer A. McCullough, Philip Lois, Noemi J Clin Med Review Background: Retinal ischaemia is present to a greater or lesser extent in all eyes with diabetic retinopathy (DR). Nonetheless, our understanding of its pathogenic mechanisms, risk factors, as well as other characteristics of retinal ischaemia in DR is very limited. To date, there is no treatment to revascularise ischaemic retina. Methods: Review of the literature highlighting the current knowledge on the topic of retinal ischaemia in DR, important observations made, and underlying gaps for which research is needed. Results: A very scarce number of clinical studies, mostly cross-sectional, have evaluated specifically retinal ischaemia in DR. Interindividual variability on its natural course and consequences, including the development of its major complications, namely diabetic macular ischaemia and proliferative diabetic retinopathy, have not been investigated. The in situ, surrounding, and distance effect of retinal ischaemia on retinal function and structure and its change over time remains also to be elucidated. Treatments to prevent the development of retinal ischaemia and, importantly, to achieve retinal reperfusion once capillary drop out has ensued, are very much needed and remain to be developed. Conclusion: Research into retinal ischaemia in diabetes should be a priority to save sight. MDPI 2023-03-21 /pmc/articles/PMC10056455/ /pubmed/36983406 http://dx.doi.org/10.3390/jcm12062406 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mohite, Ajay A. Perais, Jennifer A. McCullough, Philip Lois, Noemi Retinal Ischaemia in Diabetic Retinopathy: Understanding and Overcoming a Therapeutic Challenge |
title | Retinal Ischaemia in Diabetic Retinopathy: Understanding and Overcoming a Therapeutic Challenge |
title_full | Retinal Ischaemia in Diabetic Retinopathy: Understanding and Overcoming a Therapeutic Challenge |
title_fullStr | Retinal Ischaemia in Diabetic Retinopathy: Understanding and Overcoming a Therapeutic Challenge |
title_full_unstemmed | Retinal Ischaemia in Diabetic Retinopathy: Understanding and Overcoming a Therapeutic Challenge |
title_short | Retinal Ischaemia in Diabetic Retinopathy: Understanding and Overcoming a Therapeutic Challenge |
title_sort | retinal ischaemia in diabetic retinopathy: understanding and overcoming a therapeutic challenge |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056455/ https://www.ncbi.nlm.nih.gov/pubmed/36983406 http://dx.doi.org/10.3390/jcm12062406 |
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