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Serum Cortisol as a Biomarker of Severe Dengue

Dengue infection presents a wide range of clinical symptoms. Serum cortisol is known as a severity predictor of serious infection but is not yet clearly understood in dengue infection. We aimed to investigate the pattern of cortisol response after dengue infection and evaluate the possibility of usi...

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Autores principales: Bongsebandhu-phubhakdi, Chansuda, Supornsilchai, Vichit, Aroonparkmongkol, Suphab, Limothai, Umaporn, Tachaboon, Sasipha, Dinhuzen, Janejira, Chaisuriyong, Watchadaporn, Trongkamolchai, Supachoke, Wanpaisitkul, Mananya, Chulapornsiri, Chatchai, Tiawilai, Anongrat, Tiawilai, Thawat, Tantawichien, Terapong, Thisyakorn, Usa, Srisawat, Nattachai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056505/
https://www.ncbi.nlm.nih.gov/pubmed/36977147
http://dx.doi.org/10.3390/tropicalmed8030146
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author Bongsebandhu-phubhakdi, Chansuda
Supornsilchai, Vichit
Aroonparkmongkol, Suphab
Limothai, Umaporn
Tachaboon, Sasipha
Dinhuzen, Janejira
Chaisuriyong, Watchadaporn
Trongkamolchai, Supachoke
Wanpaisitkul, Mananya
Chulapornsiri, Chatchai
Tiawilai, Anongrat
Tiawilai, Thawat
Tantawichien, Terapong
Thisyakorn, Usa
Srisawat, Nattachai
author_facet Bongsebandhu-phubhakdi, Chansuda
Supornsilchai, Vichit
Aroonparkmongkol, Suphab
Limothai, Umaporn
Tachaboon, Sasipha
Dinhuzen, Janejira
Chaisuriyong, Watchadaporn
Trongkamolchai, Supachoke
Wanpaisitkul, Mananya
Chulapornsiri, Chatchai
Tiawilai, Anongrat
Tiawilai, Thawat
Tantawichien, Terapong
Thisyakorn, Usa
Srisawat, Nattachai
author_sort Bongsebandhu-phubhakdi, Chansuda
collection PubMed
description Dengue infection presents a wide range of clinical symptoms. Serum cortisol is known as a severity predictor of serious infection but is not yet clearly understood in dengue infection. We aimed to investigate the pattern of cortisol response after dengue infection and evaluate the possibility of using serum cortisol as the biomarker to predict the severity of dengue infection. This prospective study was conducted in Thailand during 2018. Serum cortisol and other laboratory tests were collected at four time points: day 1 at hospital admission, day 3, day of defervescence (DFV) (4–7 days post-fever onset), and day of discharge (DC). The study recruited 265 patients (median age (IQR) 17 (13, 27.5)). Approximately 10% presented severe dengue infection. Serum cortisol levels were highest on the day of admission and day 3. The best cut-off value of serum cortisol level for predicting severe dengue was 18.2 mcg/dL with an AUC of 0.62 (95% CI, 0.51, 0.74). The sensitivity, specificity, PPV and NPV were 65.4, 62.3, 16 and 94%, respectively. When we combined serum cortisol with persistent vomiting and day of fever, the AUC increased to 0.76. In summary, serum cortisol at day of admission was likely to be associated with dengue severity. Further studies may focus on the possibility of using serum cortisol as one of the biomarkers for dengue severity.
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spelling pubmed-100565052023-03-30 Serum Cortisol as a Biomarker of Severe Dengue Bongsebandhu-phubhakdi, Chansuda Supornsilchai, Vichit Aroonparkmongkol, Suphab Limothai, Umaporn Tachaboon, Sasipha Dinhuzen, Janejira Chaisuriyong, Watchadaporn Trongkamolchai, Supachoke Wanpaisitkul, Mananya Chulapornsiri, Chatchai Tiawilai, Anongrat Tiawilai, Thawat Tantawichien, Terapong Thisyakorn, Usa Srisawat, Nattachai Trop Med Infect Dis Article Dengue infection presents a wide range of clinical symptoms. Serum cortisol is known as a severity predictor of serious infection but is not yet clearly understood in dengue infection. We aimed to investigate the pattern of cortisol response after dengue infection and evaluate the possibility of using serum cortisol as the biomarker to predict the severity of dengue infection. This prospective study was conducted in Thailand during 2018. Serum cortisol and other laboratory tests were collected at four time points: day 1 at hospital admission, day 3, day of defervescence (DFV) (4–7 days post-fever onset), and day of discharge (DC). The study recruited 265 patients (median age (IQR) 17 (13, 27.5)). Approximately 10% presented severe dengue infection. Serum cortisol levels were highest on the day of admission and day 3. The best cut-off value of serum cortisol level for predicting severe dengue was 18.2 mcg/dL with an AUC of 0.62 (95% CI, 0.51, 0.74). The sensitivity, specificity, PPV and NPV were 65.4, 62.3, 16 and 94%, respectively. When we combined serum cortisol with persistent vomiting and day of fever, the AUC increased to 0.76. In summary, serum cortisol at day of admission was likely to be associated with dengue severity. Further studies may focus on the possibility of using serum cortisol as one of the biomarkers for dengue severity. MDPI 2023-02-27 /pmc/articles/PMC10056505/ /pubmed/36977147 http://dx.doi.org/10.3390/tropicalmed8030146 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bongsebandhu-phubhakdi, Chansuda
Supornsilchai, Vichit
Aroonparkmongkol, Suphab
Limothai, Umaporn
Tachaboon, Sasipha
Dinhuzen, Janejira
Chaisuriyong, Watchadaporn
Trongkamolchai, Supachoke
Wanpaisitkul, Mananya
Chulapornsiri, Chatchai
Tiawilai, Anongrat
Tiawilai, Thawat
Tantawichien, Terapong
Thisyakorn, Usa
Srisawat, Nattachai
Serum Cortisol as a Biomarker of Severe Dengue
title Serum Cortisol as a Biomarker of Severe Dengue
title_full Serum Cortisol as a Biomarker of Severe Dengue
title_fullStr Serum Cortisol as a Biomarker of Severe Dengue
title_full_unstemmed Serum Cortisol as a Biomarker of Severe Dengue
title_short Serum Cortisol as a Biomarker of Severe Dengue
title_sort serum cortisol as a biomarker of severe dengue
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056505/
https://www.ncbi.nlm.nih.gov/pubmed/36977147
http://dx.doi.org/10.3390/tropicalmed8030146
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