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Epstein–Barr Virus History and Pathogenesis
Epstein–Barr virus (EBV) is the first identified human oncogenic virus that can establish asymptomatic life-long persistence. It is associated with a large spectrum of diseases, including benign diseases, a number of lymphoid malignancies, and epithelial cancers. EBV can also transform quiescent B l...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056551/ https://www.ncbi.nlm.nih.gov/pubmed/36992423 http://dx.doi.org/10.3390/v15030714 |
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author | Yu, Hui Robertson, Erle S. |
author_facet | Yu, Hui Robertson, Erle S. |
author_sort | Yu, Hui |
collection | PubMed |
description | Epstein–Barr virus (EBV) is the first identified human oncogenic virus that can establish asymptomatic life-long persistence. It is associated with a large spectrum of diseases, including benign diseases, a number of lymphoid malignancies, and epithelial cancers. EBV can also transform quiescent B lymphocytes into lymphoblastoid cell lines (LCLs) in vitro. Although EBV molecular biology and EBV-related diseases have been continuously investigated for nearly 60 years, the mechanism of viral-mediated transformation, as well as the precise role of EBV in promoting these diseases, remain a major challenge yet to be completely explored. This review will highlight the history of EBV and current advances in EBV-associated diseases, focusing on how this virus provides a paradigm for exploiting the many insights identified through interplay between EBV and its host during oncogenesis, and other related non-malignant disorders. |
format | Online Article Text |
id | pubmed-10056551 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100565512023-03-30 Epstein–Barr Virus History and Pathogenesis Yu, Hui Robertson, Erle S. Viruses Review Epstein–Barr virus (EBV) is the first identified human oncogenic virus that can establish asymptomatic life-long persistence. It is associated with a large spectrum of diseases, including benign diseases, a number of lymphoid malignancies, and epithelial cancers. EBV can also transform quiescent B lymphocytes into lymphoblastoid cell lines (LCLs) in vitro. Although EBV molecular biology and EBV-related diseases have been continuously investigated for nearly 60 years, the mechanism of viral-mediated transformation, as well as the precise role of EBV in promoting these diseases, remain a major challenge yet to be completely explored. This review will highlight the history of EBV and current advances in EBV-associated diseases, focusing on how this virus provides a paradigm for exploiting the many insights identified through interplay between EBV and its host during oncogenesis, and other related non-malignant disorders. MDPI 2023-03-09 /pmc/articles/PMC10056551/ /pubmed/36992423 http://dx.doi.org/10.3390/v15030714 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yu, Hui Robertson, Erle S. Epstein–Barr Virus History and Pathogenesis |
title | Epstein–Barr Virus History and Pathogenesis |
title_full | Epstein–Barr Virus History and Pathogenesis |
title_fullStr | Epstein–Barr Virus History and Pathogenesis |
title_full_unstemmed | Epstein–Barr Virus History and Pathogenesis |
title_short | Epstein–Barr Virus History and Pathogenesis |
title_sort | epstein–barr virus history and pathogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056551/ https://www.ncbi.nlm.nih.gov/pubmed/36992423 http://dx.doi.org/10.3390/v15030714 |
work_keys_str_mv | AT yuhui epsteinbarrvirushistoryandpathogenesis AT robertsonerles epsteinbarrvirushistoryandpathogenesis |