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Epstein–Barr Virus History and Pathogenesis

Epstein–Barr virus (EBV) is the first identified human oncogenic virus that can establish asymptomatic life-long persistence. It is associated with a large spectrum of diseases, including benign diseases, a number of lymphoid malignancies, and epithelial cancers. EBV can also transform quiescent B l...

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Autores principales: Yu, Hui, Robertson, Erle S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056551/
https://www.ncbi.nlm.nih.gov/pubmed/36992423
http://dx.doi.org/10.3390/v15030714
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author Yu, Hui
Robertson, Erle S.
author_facet Yu, Hui
Robertson, Erle S.
author_sort Yu, Hui
collection PubMed
description Epstein–Barr virus (EBV) is the first identified human oncogenic virus that can establish asymptomatic life-long persistence. It is associated with a large spectrum of diseases, including benign diseases, a number of lymphoid malignancies, and epithelial cancers. EBV can also transform quiescent B lymphocytes into lymphoblastoid cell lines (LCLs) in vitro. Although EBV molecular biology and EBV-related diseases have been continuously investigated for nearly 60 years, the mechanism of viral-mediated transformation, as well as the precise role of EBV in promoting these diseases, remain a major challenge yet to be completely explored. This review will highlight the history of EBV and current advances in EBV-associated diseases, focusing on how this virus provides a paradigm for exploiting the many insights identified through interplay between EBV and its host during oncogenesis, and other related non-malignant disorders.
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spelling pubmed-100565512023-03-30 Epstein–Barr Virus History and Pathogenesis Yu, Hui Robertson, Erle S. Viruses Review Epstein–Barr virus (EBV) is the first identified human oncogenic virus that can establish asymptomatic life-long persistence. It is associated with a large spectrum of diseases, including benign diseases, a number of lymphoid malignancies, and epithelial cancers. EBV can also transform quiescent B lymphocytes into lymphoblastoid cell lines (LCLs) in vitro. Although EBV molecular biology and EBV-related diseases have been continuously investigated for nearly 60 years, the mechanism of viral-mediated transformation, as well as the precise role of EBV in promoting these diseases, remain a major challenge yet to be completely explored. This review will highlight the history of EBV and current advances in EBV-associated diseases, focusing on how this virus provides a paradigm for exploiting the many insights identified through interplay between EBV and its host during oncogenesis, and other related non-malignant disorders. MDPI 2023-03-09 /pmc/articles/PMC10056551/ /pubmed/36992423 http://dx.doi.org/10.3390/v15030714 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yu, Hui
Robertson, Erle S.
Epstein–Barr Virus History and Pathogenesis
title Epstein–Barr Virus History and Pathogenesis
title_full Epstein–Barr Virus History and Pathogenesis
title_fullStr Epstein–Barr Virus History and Pathogenesis
title_full_unstemmed Epstein–Barr Virus History and Pathogenesis
title_short Epstein–Barr Virus History and Pathogenesis
title_sort epstein–barr virus history and pathogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056551/
https://www.ncbi.nlm.nih.gov/pubmed/36992423
http://dx.doi.org/10.3390/v15030714
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