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Cerebral Cryptococcosis Associated with CD4+ T-lymphocytopenia in Non-HIV Patients after SARS-CoV-2 Infection: Case Series in a Specialized Institute in Lima, Peru
Cases of cryptococcosis have been reported in patients with COVID-19. The majority are in patients with severe symptoms or who received immunosuppressants. However, there is still no clear association between COVID-19 and cryptococcosis. We report eight cases of cerebral cryptococcosis associated wi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056744/ https://www.ncbi.nlm.nih.gov/pubmed/36977183 http://dx.doi.org/10.3390/tropicalmed8030182 |
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author | Huamani-Córdova, Juana M. Hueda-Zavaleta, Miguel Vargas-Bellina, Victor Simbron-Ribbeck, Lourdes Chong-Chinchay, Katty del Rosario Gómez de la Torre, Juan Carlos Benítes-Zapata, Vicente A. |
author_facet | Huamani-Córdova, Juana M. Hueda-Zavaleta, Miguel Vargas-Bellina, Victor Simbron-Ribbeck, Lourdes Chong-Chinchay, Katty del Rosario Gómez de la Torre, Juan Carlos Benítes-Zapata, Vicente A. |
author_sort | Huamani-Córdova, Juana M. |
collection | PubMed |
description | Cases of cryptococcosis have been reported in patients with COVID-19. The majority are in patients with severe symptoms or who received immunosuppressants. However, there is still no clear association between COVID-19 and cryptococcosis. We report eight cases of cerebral cryptococcosis associated with CD4+ T lymphocytopenia in non-HIV patients after SARS-CoV-2 infection. The median age was 57 years and 5/8 were male. In addition, 2/8 of patients had diabetes, and 8/8 had a history of mild COVID-19, with a median of 75 days before diagnosis of cerebral cryptococcosis. All patients denied having received prior immunosuppressive therapy. The most frequent symptoms were confusion (8/8), headache (7/8), vomiting (6/8), and nausea (6/8) All patients were diagnosed by isolating Cryptococcus in cerebrospinal fluid. The median CD4+ and CD8+ T lymphocytes were 247 and 173.5, respectively. Other causes of immunosuppression, such as HIV or HTLV infection, were excluded in all patients. Finally, three patients died, and one presented long-term visual and auditory sequelae. The CD4+/CD8+ T lymphocyte count normalized during follow-up in those patients who survived. We hypothesize that CD4+ T lymphocytopenia in the patients in this case series could increase the risk of cryptococcosis after SARS-CoV-2 infection. |
format | Online Article Text |
id | pubmed-10056744 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100567442023-03-30 Cerebral Cryptococcosis Associated with CD4+ T-lymphocytopenia in Non-HIV Patients after SARS-CoV-2 Infection: Case Series in a Specialized Institute in Lima, Peru Huamani-Córdova, Juana M. Hueda-Zavaleta, Miguel Vargas-Bellina, Victor Simbron-Ribbeck, Lourdes Chong-Chinchay, Katty del Rosario Gómez de la Torre, Juan Carlos Benítes-Zapata, Vicente A. Trop Med Infect Dis Case Report Cases of cryptococcosis have been reported in patients with COVID-19. The majority are in patients with severe symptoms or who received immunosuppressants. However, there is still no clear association between COVID-19 and cryptococcosis. We report eight cases of cerebral cryptococcosis associated with CD4+ T lymphocytopenia in non-HIV patients after SARS-CoV-2 infection. The median age was 57 years and 5/8 were male. In addition, 2/8 of patients had diabetes, and 8/8 had a history of mild COVID-19, with a median of 75 days before diagnosis of cerebral cryptococcosis. All patients denied having received prior immunosuppressive therapy. The most frequent symptoms were confusion (8/8), headache (7/8), vomiting (6/8), and nausea (6/8) All patients were diagnosed by isolating Cryptococcus in cerebrospinal fluid. The median CD4+ and CD8+ T lymphocytes were 247 and 173.5, respectively. Other causes of immunosuppression, such as HIV or HTLV infection, were excluded in all patients. Finally, three patients died, and one presented long-term visual and auditory sequelae. The CD4+/CD8+ T lymphocyte count normalized during follow-up in those patients who survived. We hypothesize that CD4+ T lymphocytopenia in the patients in this case series could increase the risk of cryptococcosis after SARS-CoV-2 infection. MDPI 2023-03-22 /pmc/articles/PMC10056744/ /pubmed/36977183 http://dx.doi.org/10.3390/tropicalmed8030182 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Huamani-Córdova, Juana M. Hueda-Zavaleta, Miguel Vargas-Bellina, Victor Simbron-Ribbeck, Lourdes Chong-Chinchay, Katty del Rosario Gómez de la Torre, Juan Carlos Benítes-Zapata, Vicente A. Cerebral Cryptococcosis Associated with CD4+ T-lymphocytopenia in Non-HIV Patients after SARS-CoV-2 Infection: Case Series in a Specialized Institute in Lima, Peru |
title | Cerebral Cryptococcosis Associated with CD4+ T-lymphocytopenia in Non-HIV Patients after SARS-CoV-2 Infection: Case Series in a Specialized Institute in Lima, Peru |
title_full | Cerebral Cryptococcosis Associated with CD4+ T-lymphocytopenia in Non-HIV Patients after SARS-CoV-2 Infection: Case Series in a Specialized Institute in Lima, Peru |
title_fullStr | Cerebral Cryptococcosis Associated with CD4+ T-lymphocytopenia in Non-HIV Patients after SARS-CoV-2 Infection: Case Series in a Specialized Institute in Lima, Peru |
title_full_unstemmed | Cerebral Cryptococcosis Associated with CD4+ T-lymphocytopenia in Non-HIV Patients after SARS-CoV-2 Infection: Case Series in a Specialized Institute in Lima, Peru |
title_short | Cerebral Cryptococcosis Associated with CD4+ T-lymphocytopenia in Non-HIV Patients after SARS-CoV-2 Infection: Case Series in a Specialized Institute in Lima, Peru |
title_sort | cerebral cryptococcosis associated with cd4+ t-lymphocytopenia in non-hiv patients after sars-cov-2 infection: case series in a specialized institute in lima, peru |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056744/ https://www.ncbi.nlm.nih.gov/pubmed/36977183 http://dx.doi.org/10.3390/tropicalmed8030182 |
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