Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review

The high prevalence of obesity and of its associated diseases is a major problem worldwide. Genetic predisposition and the influence of environmental factors contribute to the development of obesity. Changes in the structure and functional activity of genes encoding adipocytokines are involved in th...

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Autores principales: Bairqdar, Ahmad, Ivanoshchuk, Dinara, Shakhtshneider, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056771/
https://www.ncbi.nlm.nih.gov/pubmed/36983642
http://dx.doi.org/10.3390/jpm13030460
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author Bairqdar, Ahmad
Ivanoshchuk, Dinara
Shakhtshneider, Elena
author_facet Bairqdar, Ahmad
Ivanoshchuk, Dinara
Shakhtshneider, Elena
author_sort Bairqdar, Ahmad
collection PubMed
description The high prevalence of obesity and of its associated diseases is a major problem worldwide. Genetic predisposition and the influence of environmental factors contribute to the development of obesity. Changes in the structure and functional activity of genes encoding adipocytokines are involved in the predisposition to weight gain and obesity. In this review, variants in genes associated with adipocyte function are examined, as are variants in genes associated with metabolic aberrations and the accompanying disorders in visceral obesity.
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spelling pubmed-100567712023-03-30 Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review Bairqdar, Ahmad Ivanoshchuk, Dinara Shakhtshneider, Elena J Pers Med Review The high prevalence of obesity and of its associated diseases is a major problem worldwide. Genetic predisposition and the influence of environmental factors contribute to the development of obesity. Changes in the structure and functional activity of genes encoding adipocytokines are involved in the predisposition to weight gain and obesity. In this review, variants in genes associated with adipocyte function are examined, as are variants in genes associated with metabolic aberrations and the accompanying disorders in visceral obesity. MDPI 2023-03-01 /pmc/articles/PMC10056771/ /pubmed/36983642 http://dx.doi.org/10.3390/jpm13030460 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bairqdar, Ahmad
Ivanoshchuk, Dinara
Shakhtshneider, Elena
Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review
title Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review
title_full Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review
title_fullStr Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review
title_full_unstemmed Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review
title_short Functionally Significant Variants in Genes Associated with Abdominal Obesity: A Review
title_sort functionally significant variants in genes associated with abdominal obesity: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056771/
https://www.ncbi.nlm.nih.gov/pubmed/36983642
http://dx.doi.org/10.3390/jpm13030460
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