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Size-Controllable Nanosystem with Double Responsive for Deep Photodynamic Therapy
Photodynamic therapy (PDT) is a promising strategy for cancer treatment. However, a poor tissue penetration of activation light and low target specificity seriously hindered the clinical application of PDT. Here, we designed and constructed a size-controllable nanosystem (UPH) with inside-out respon...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056800/ https://www.ncbi.nlm.nih.gov/pubmed/36986801 http://dx.doi.org/10.3390/pharmaceutics15030940 |
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author | Wan, Shuang-Shuang Tao, Jun Wu, Qian Liu, Wu-Rui Ding, Xian-Guang Zhang, Xian-Zheng |
author_facet | Wan, Shuang-Shuang Tao, Jun Wu, Qian Liu, Wu-Rui Ding, Xian-Guang Zhang, Xian-Zheng |
author_sort | Wan, Shuang-Shuang |
collection | PubMed |
description | Photodynamic therapy (PDT) is a promising strategy for cancer treatment. However, a poor tissue penetration of activation light and low target specificity seriously hindered the clinical application of PDT. Here, we designed and constructed a size-controllable nanosystem (UPH) with inside-out responsive for deep PDT with enhanced biosafety. To obtain nanoparticles with the best quantum yield, a series of core-shell nanoparticles (UCNP@nPCN) with different thicknesses were synthesized by a layer-by-layer self-assembly method to incorporate a porphyritic porous coordination network (PCN) onto the surface of upconverting nanoparticles (UCNPs), followed by coating with hyaluronic acid (HA) on the surface of nanoparticles with optimized thickness to form the UPH nanoparticles. With the aid of HA, the UPH nanoparticles were capable of preferentially enriching in tumor sites and specific endocytosis by CD44 receptors as well as responsive degradation by hyaluronidase in cancer cells after intravenous administration. Subsequently, after being activated by strong penetrating 980 nm near-infrared light (NIR), the UPH nanoparticles efficiently converted oxygen into strongly oxidizing reactive oxygen species based on the fluorescence resonance energy transfer (FRET) effect, thereby significantly inhibiting tumor growth. Experimental results in vitro and in vivo indicated that such dual-responsive nanoparticles successfully realize the photodynamic therapy of deep-seated cancer with negligible side effects, which showed great potential for potential clinical translational research. |
format | Online Article Text |
id | pubmed-10056800 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100568002023-03-30 Size-Controllable Nanosystem with Double Responsive for Deep Photodynamic Therapy Wan, Shuang-Shuang Tao, Jun Wu, Qian Liu, Wu-Rui Ding, Xian-Guang Zhang, Xian-Zheng Pharmaceutics Article Photodynamic therapy (PDT) is a promising strategy for cancer treatment. However, a poor tissue penetration of activation light and low target specificity seriously hindered the clinical application of PDT. Here, we designed and constructed a size-controllable nanosystem (UPH) with inside-out responsive for deep PDT with enhanced biosafety. To obtain nanoparticles with the best quantum yield, a series of core-shell nanoparticles (UCNP@nPCN) with different thicknesses were synthesized by a layer-by-layer self-assembly method to incorporate a porphyritic porous coordination network (PCN) onto the surface of upconverting nanoparticles (UCNPs), followed by coating with hyaluronic acid (HA) on the surface of nanoparticles with optimized thickness to form the UPH nanoparticles. With the aid of HA, the UPH nanoparticles were capable of preferentially enriching in tumor sites and specific endocytosis by CD44 receptors as well as responsive degradation by hyaluronidase in cancer cells after intravenous administration. Subsequently, after being activated by strong penetrating 980 nm near-infrared light (NIR), the UPH nanoparticles efficiently converted oxygen into strongly oxidizing reactive oxygen species based on the fluorescence resonance energy transfer (FRET) effect, thereby significantly inhibiting tumor growth. Experimental results in vitro and in vivo indicated that such dual-responsive nanoparticles successfully realize the photodynamic therapy of deep-seated cancer with negligible side effects, which showed great potential for potential clinical translational research. MDPI 2023-03-14 /pmc/articles/PMC10056800/ /pubmed/36986801 http://dx.doi.org/10.3390/pharmaceutics15030940 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wan, Shuang-Shuang Tao, Jun Wu, Qian Liu, Wu-Rui Ding, Xian-Guang Zhang, Xian-Zheng Size-Controllable Nanosystem with Double Responsive for Deep Photodynamic Therapy |
title | Size-Controllable Nanosystem with Double Responsive for Deep Photodynamic Therapy |
title_full | Size-Controllable Nanosystem with Double Responsive for Deep Photodynamic Therapy |
title_fullStr | Size-Controllable Nanosystem with Double Responsive for Deep Photodynamic Therapy |
title_full_unstemmed | Size-Controllable Nanosystem with Double Responsive for Deep Photodynamic Therapy |
title_short | Size-Controllable Nanosystem with Double Responsive for Deep Photodynamic Therapy |
title_sort | size-controllable nanosystem with double responsive for deep photodynamic therapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056800/ https://www.ncbi.nlm.nih.gov/pubmed/36986801 http://dx.doi.org/10.3390/pharmaceutics15030940 |
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