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Current Trends in Neoantigen-Based Cancer Vaccines

Cancer immunotherapies are treatments that use drugs or cells to activate patients’ own immune systems against cancer cells. Among them, cancer vaccines have recently been rapidly developed. Based on tumor-specific antigens referred to as neoantigens, these vaccines can be in various forms such as m...

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Autores principales: Ho, Szu-Ying, Chang, Che-Mai, Liao, Hsin-Ni, Chou, Wan-Hsuan, Guo, Chin-Lin, Yen, Yun, Nakamura, Yusuke, Chang, Wei-Chiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056833/
https://www.ncbi.nlm.nih.gov/pubmed/36986491
http://dx.doi.org/10.3390/ph16030392
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author Ho, Szu-Ying
Chang, Che-Mai
Liao, Hsin-Ni
Chou, Wan-Hsuan
Guo, Chin-Lin
Yen, Yun
Nakamura, Yusuke
Chang, Wei-Chiao
author_facet Ho, Szu-Ying
Chang, Che-Mai
Liao, Hsin-Ni
Chou, Wan-Hsuan
Guo, Chin-Lin
Yen, Yun
Nakamura, Yusuke
Chang, Wei-Chiao
author_sort Ho, Szu-Ying
collection PubMed
description Cancer immunotherapies are treatments that use drugs or cells to activate patients’ own immune systems against cancer cells. Among them, cancer vaccines have recently been rapidly developed. Based on tumor-specific antigens referred to as neoantigens, these vaccines can be in various forms such as messenger (m)RNA and synthetic peptides to activate cytotoxic T cells and act with or without dendritic cells. Growing evidence suggests that neoantigen-based cancer vaccines possess a very promising future, yet the processes of immune recognition and activation to relay identification of a neoantigen through the histocompatibility complex (MHC) and T-cell receptor (TCR) remain unclear. Here, we describe features of neoantigens and the biological process of validating neoantigens, along with a discussion of recent progress in the scientific development and clinical applications of neoantigen-based cancer vaccines.
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spelling pubmed-100568332023-03-30 Current Trends in Neoantigen-Based Cancer Vaccines Ho, Szu-Ying Chang, Che-Mai Liao, Hsin-Ni Chou, Wan-Hsuan Guo, Chin-Lin Yen, Yun Nakamura, Yusuke Chang, Wei-Chiao Pharmaceuticals (Basel) Review Cancer immunotherapies are treatments that use drugs or cells to activate patients’ own immune systems against cancer cells. Among them, cancer vaccines have recently been rapidly developed. Based on tumor-specific antigens referred to as neoantigens, these vaccines can be in various forms such as messenger (m)RNA and synthetic peptides to activate cytotoxic T cells and act with or without dendritic cells. Growing evidence suggests that neoantigen-based cancer vaccines possess a very promising future, yet the processes of immune recognition and activation to relay identification of a neoantigen through the histocompatibility complex (MHC) and T-cell receptor (TCR) remain unclear. Here, we describe features of neoantigens and the biological process of validating neoantigens, along with a discussion of recent progress in the scientific development and clinical applications of neoantigen-based cancer vaccines. MDPI 2023-03-05 /pmc/articles/PMC10056833/ /pubmed/36986491 http://dx.doi.org/10.3390/ph16030392 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ho, Szu-Ying
Chang, Che-Mai
Liao, Hsin-Ni
Chou, Wan-Hsuan
Guo, Chin-Lin
Yen, Yun
Nakamura, Yusuke
Chang, Wei-Chiao
Current Trends in Neoantigen-Based Cancer Vaccines
title Current Trends in Neoantigen-Based Cancer Vaccines
title_full Current Trends in Neoantigen-Based Cancer Vaccines
title_fullStr Current Trends in Neoantigen-Based Cancer Vaccines
title_full_unstemmed Current Trends in Neoantigen-Based Cancer Vaccines
title_short Current Trends in Neoantigen-Based Cancer Vaccines
title_sort current trends in neoantigen-based cancer vaccines
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056833/
https://www.ncbi.nlm.nih.gov/pubmed/36986491
http://dx.doi.org/10.3390/ph16030392
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