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Implementation of Systematic Bioanalysis of Antibody–Drug Conjugates for Preclinical Pharmacokinetic Study of Ado-Trastuzumab Emtansine (T-DM1) in Rats

Antibody–drug conjugates (ADCs) are composed of monoclonal antibodies covalently bound to cytotoxic drugs by a linker. They are designed to selectively bind target antigens and present a promising cancer treatment without the debilitating side effects of conventional chemotherapies. Ado-trastuzumab...

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Detalles Bibliográficos
Autores principales:	Jeon, Eun-Jeong, Han, Ju-Hee, Seo, Youjin, Koh, Eun Mi, Han, Kang-Hyun, Hwang, Kyunghwa, Jung, Kyung Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056844/ https://www.ncbi.nlm.nih.gov/pubmed/36986616 http://dx.doi.org/10.3390/pharmaceutics15030756

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