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Alternate-Day Fasting Combined with Exercise: Effect on Sleep in Adults with Obesity and NAFLD

Objective: This study investigated how alternate-day fasting (ADF) combined with aerobic exercise impacts body weight and sleep in adults with non-alcoholic fatty liver disease (NAFLD). Methods: Adults with obesity and NAFLD (n = 80) were randomized into one of four groups for 3 months: combination...

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Autores principales: Ezpeleta, Mark, Gabel, Kelsey, Cienfuegos, Sofia, Kalam, Faiza, Lin, Shuhao, Pavlou, Vasiliki, Varady, Krista A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056902/
https://www.ncbi.nlm.nih.gov/pubmed/36986128
http://dx.doi.org/10.3390/nu15061398
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author Ezpeleta, Mark
Gabel, Kelsey
Cienfuegos, Sofia
Kalam, Faiza
Lin, Shuhao
Pavlou, Vasiliki
Varady, Krista A.
author_facet Ezpeleta, Mark
Gabel, Kelsey
Cienfuegos, Sofia
Kalam, Faiza
Lin, Shuhao
Pavlou, Vasiliki
Varady, Krista A.
author_sort Ezpeleta, Mark
collection PubMed
description Objective: This study investigated how alternate-day fasting (ADF) combined with aerobic exercise impacts body weight and sleep in adults with non-alcoholic fatty liver disease (NAFLD). Methods: Adults with obesity and NAFLD (n = 80) were randomized into one of four groups for 3 months: combination of ADF (600 kcal “fast day,” alternated with an ad libitum intake “feast day”) and moderate-intensity aerobic exercise (five sessions per week, 60 min/session); ADF alone; exercise alone; or a no-intervention control group. Results: By month 3, body weight and intrahepatic triglyceride content decreased (p < 0.001, group × time interaction) in the combination group versus the exercise group and control group, but not versus the ADF group. Sleep quality, measured by the Pittsburgh Sleep Quality Inventory (PSQI), did not change in the combination group (baseline: 6.0 ± 0.7; month 3: 5.6 ± 0.7), ADF group (baseline: 8.9 ± 1.0; month 3: 7.5 ± 0.8), or exercise group (baseline: 6.4 ± 0.6; month 3: 6.7 ± 0.6), versus controls (baseline: 5.5 ± 0.7; month 3: 4.6 ± 0.5). Wake time, bedtime, sleep duration, and insomnia severity did not change (no group x time interaction) over the course of the study in any group. Risk for obstructive sleep apnea was present in 30% of combination subjects, 75% of ADF subjects, 40% of exercise subjects, and 75% of controls, and did not change in the intervention groups, versus controls, by month 3. No associations were observed between changes in body weight, intrahepatic triglyceride content, and any sleep outcome. Conclusions: The weight loss induced by ADF combined with exercise does not improve sleep quality, duration, insomnia severity, or risk of obstructive sleep apnea in individuals with NAFLD.
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spelling pubmed-100569022023-03-30 Alternate-Day Fasting Combined with Exercise: Effect on Sleep in Adults with Obesity and NAFLD Ezpeleta, Mark Gabel, Kelsey Cienfuegos, Sofia Kalam, Faiza Lin, Shuhao Pavlou, Vasiliki Varady, Krista A. Nutrients Article Objective: This study investigated how alternate-day fasting (ADF) combined with aerobic exercise impacts body weight and sleep in adults with non-alcoholic fatty liver disease (NAFLD). Methods: Adults with obesity and NAFLD (n = 80) were randomized into one of four groups for 3 months: combination of ADF (600 kcal “fast day,” alternated with an ad libitum intake “feast day”) and moderate-intensity aerobic exercise (five sessions per week, 60 min/session); ADF alone; exercise alone; or a no-intervention control group. Results: By month 3, body weight and intrahepatic triglyceride content decreased (p < 0.001, group × time interaction) in the combination group versus the exercise group and control group, but not versus the ADF group. Sleep quality, measured by the Pittsburgh Sleep Quality Inventory (PSQI), did not change in the combination group (baseline: 6.0 ± 0.7; month 3: 5.6 ± 0.7), ADF group (baseline: 8.9 ± 1.0; month 3: 7.5 ± 0.8), or exercise group (baseline: 6.4 ± 0.6; month 3: 6.7 ± 0.6), versus controls (baseline: 5.5 ± 0.7; month 3: 4.6 ± 0.5). Wake time, bedtime, sleep duration, and insomnia severity did not change (no group x time interaction) over the course of the study in any group. Risk for obstructive sleep apnea was present in 30% of combination subjects, 75% of ADF subjects, 40% of exercise subjects, and 75% of controls, and did not change in the intervention groups, versus controls, by month 3. No associations were observed between changes in body weight, intrahepatic triglyceride content, and any sleep outcome. Conclusions: The weight loss induced by ADF combined with exercise does not improve sleep quality, duration, insomnia severity, or risk of obstructive sleep apnea in individuals with NAFLD. MDPI 2023-03-14 /pmc/articles/PMC10056902/ /pubmed/36986128 http://dx.doi.org/10.3390/nu15061398 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ezpeleta, Mark
Gabel, Kelsey
Cienfuegos, Sofia
Kalam, Faiza
Lin, Shuhao
Pavlou, Vasiliki
Varady, Krista A.
Alternate-Day Fasting Combined with Exercise: Effect on Sleep in Adults with Obesity and NAFLD
title Alternate-Day Fasting Combined with Exercise: Effect on Sleep in Adults with Obesity and NAFLD
title_full Alternate-Day Fasting Combined with Exercise: Effect on Sleep in Adults with Obesity and NAFLD
title_fullStr Alternate-Day Fasting Combined with Exercise: Effect on Sleep in Adults with Obesity and NAFLD
title_full_unstemmed Alternate-Day Fasting Combined with Exercise: Effect on Sleep in Adults with Obesity and NAFLD
title_short Alternate-Day Fasting Combined with Exercise: Effect on Sleep in Adults with Obesity and NAFLD
title_sort alternate-day fasting combined with exercise: effect on sleep in adults with obesity and nafld
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056902/
https://www.ncbi.nlm.nih.gov/pubmed/36986128
http://dx.doi.org/10.3390/nu15061398
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