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Intragastric Carbon Dioxide Release Prolongs the Gastric Residence Time of Postprandially Administered Caffeine

Sparkling water is said to increase gastric motility by the release of carbon dioxide, thereby potentially affecting the pharmacokinetics of orally administered drugs. The hypothesis of the present work was that the induction of gastric motility by intragastric release of carbon dioxide from efferve...

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Autores principales: Senekowitsch, Stefan, Foja, Constantin, Wildgrube, Toni, Schick, Philipp, Rosenbaum, Christoph, Krause, Julius, Brokmann, Friederike, Kromrey, Marie-Luise, Engeli, Stefan, Weitschies, Werner, Grimm, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056953/
https://www.ncbi.nlm.nih.gov/pubmed/36986872
http://dx.doi.org/10.3390/pharmaceutics15031012
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author Senekowitsch, Stefan
Foja, Constantin
Wildgrube, Toni
Schick, Philipp
Rosenbaum, Christoph
Krause, Julius
Brokmann, Friederike
Kromrey, Marie-Luise
Engeli, Stefan
Weitschies, Werner
Grimm, Michael
author_facet Senekowitsch, Stefan
Foja, Constantin
Wildgrube, Toni
Schick, Philipp
Rosenbaum, Christoph
Krause, Julius
Brokmann, Friederike
Kromrey, Marie-Luise
Engeli, Stefan
Weitschies, Werner
Grimm, Michael
author_sort Senekowitsch, Stefan
collection PubMed
description Sparkling water is said to increase gastric motility by the release of carbon dioxide, thereby potentially affecting the pharmacokinetics of orally administered drugs. The hypothesis of the present work was that the induction of gastric motility by intragastric release of carbon dioxide from effervescent granules could promote the mixing of drugs into the chyme under postprandial conditions, resulting in a prolonged drug absorption. For this purpose, an effervescent and a non-effervescent granule formulation of caffeine as a marker for gastric emptying were developed. In a three-way crossover study with twelve healthy volunteers, the salivary caffeine pharmacokinetics, after administration of the effervescent granules with still water and the administration of the non-effervescent granules with still and sparkling water, were investigated after intake of a standard meal. While the administration of the effervescent granules with 240 mL of still water led to a significantly prolonged gastric residence of the substance compared to the administration of the non-effervescent granules with 240 mL still water, the application of the non-effervescent granules with 240 mL sparkling water did not prolong gastric residence via mixing into caloric chyme. Overall, the mixing of caffeine into the chyme following the administration of the effervescent granules did not seem to be a motility mediated process.
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spelling pubmed-100569532023-03-30 Intragastric Carbon Dioxide Release Prolongs the Gastric Residence Time of Postprandially Administered Caffeine Senekowitsch, Stefan Foja, Constantin Wildgrube, Toni Schick, Philipp Rosenbaum, Christoph Krause, Julius Brokmann, Friederike Kromrey, Marie-Luise Engeli, Stefan Weitschies, Werner Grimm, Michael Pharmaceutics Article Sparkling water is said to increase gastric motility by the release of carbon dioxide, thereby potentially affecting the pharmacokinetics of orally administered drugs. The hypothesis of the present work was that the induction of gastric motility by intragastric release of carbon dioxide from effervescent granules could promote the mixing of drugs into the chyme under postprandial conditions, resulting in a prolonged drug absorption. For this purpose, an effervescent and a non-effervescent granule formulation of caffeine as a marker for gastric emptying were developed. In a three-way crossover study with twelve healthy volunteers, the salivary caffeine pharmacokinetics, after administration of the effervescent granules with still water and the administration of the non-effervescent granules with still and sparkling water, were investigated after intake of a standard meal. While the administration of the effervescent granules with 240 mL of still water led to a significantly prolonged gastric residence of the substance compared to the administration of the non-effervescent granules with 240 mL still water, the application of the non-effervescent granules with 240 mL sparkling water did not prolong gastric residence via mixing into caloric chyme. Overall, the mixing of caffeine into the chyme following the administration of the effervescent granules did not seem to be a motility mediated process. MDPI 2023-03-22 /pmc/articles/PMC10056953/ /pubmed/36986872 http://dx.doi.org/10.3390/pharmaceutics15031012 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Senekowitsch, Stefan
Foja, Constantin
Wildgrube, Toni
Schick, Philipp
Rosenbaum, Christoph
Krause, Julius
Brokmann, Friederike
Kromrey, Marie-Luise
Engeli, Stefan
Weitschies, Werner
Grimm, Michael
Intragastric Carbon Dioxide Release Prolongs the Gastric Residence Time of Postprandially Administered Caffeine
title Intragastric Carbon Dioxide Release Prolongs the Gastric Residence Time of Postprandially Administered Caffeine
title_full Intragastric Carbon Dioxide Release Prolongs the Gastric Residence Time of Postprandially Administered Caffeine
title_fullStr Intragastric Carbon Dioxide Release Prolongs the Gastric Residence Time of Postprandially Administered Caffeine
title_full_unstemmed Intragastric Carbon Dioxide Release Prolongs the Gastric Residence Time of Postprandially Administered Caffeine
title_short Intragastric Carbon Dioxide Release Prolongs the Gastric Residence Time of Postprandially Administered Caffeine
title_sort intragastric carbon dioxide release prolongs the gastric residence time of postprandially administered caffeine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056953/
https://www.ncbi.nlm.nih.gov/pubmed/36986872
http://dx.doi.org/10.3390/pharmaceutics15031012
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