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Intragastric Carbon Dioxide Release Prolongs the Gastric Residence Time of Postprandially Administered Caffeine
Sparkling water is said to increase gastric motility by the release of carbon dioxide, thereby potentially affecting the pharmacokinetics of orally administered drugs. The hypothesis of the present work was that the induction of gastric motility by intragastric release of carbon dioxide from efferve...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056953/ https://www.ncbi.nlm.nih.gov/pubmed/36986872 http://dx.doi.org/10.3390/pharmaceutics15031012 |
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author | Senekowitsch, Stefan Foja, Constantin Wildgrube, Toni Schick, Philipp Rosenbaum, Christoph Krause, Julius Brokmann, Friederike Kromrey, Marie-Luise Engeli, Stefan Weitschies, Werner Grimm, Michael |
author_facet | Senekowitsch, Stefan Foja, Constantin Wildgrube, Toni Schick, Philipp Rosenbaum, Christoph Krause, Julius Brokmann, Friederike Kromrey, Marie-Luise Engeli, Stefan Weitschies, Werner Grimm, Michael |
author_sort | Senekowitsch, Stefan |
collection | PubMed |
description | Sparkling water is said to increase gastric motility by the release of carbon dioxide, thereby potentially affecting the pharmacokinetics of orally administered drugs. The hypothesis of the present work was that the induction of gastric motility by intragastric release of carbon dioxide from effervescent granules could promote the mixing of drugs into the chyme under postprandial conditions, resulting in a prolonged drug absorption. For this purpose, an effervescent and a non-effervescent granule formulation of caffeine as a marker for gastric emptying were developed. In a three-way crossover study with twelve healthy volunteers, the salivary caffeine pharmacokinetics, after administration of the effervescent granules with still water and the administration of the non-effervescent granules with still and sparkling water, were investigated after intake of a standard meal. While the administration of the effervescent granules with 240 mL of still water led to a significantly prolonged gastric residence of the substance compared to the administration of the non-effervescent granules with 240 mL still water, the application of the non-effervescent granules with 240 mL sparkling water did not prolong gastric residence via mixing into caloric chyme. Overall, the mixing of caffeine into the chyme following the administration of the effervescent granules did not seem to be a motility mediated process. |
format | Online Article Text |
id | pubmed-10056953 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100569532023-03-30 Intragastric Carbon Dioxide Release Prolongs the Gastric Residence Time of Postprandially Administered Caffeine Senekowitsch, Stefan Foja, Constantin Wildgrube, Toni Schick, Philipp Rosenbaum, Christoph Krause, Julius Brokmann, Friederike Kromrey, Marie-Luise Engeli, Stefan Weitschies, Werner Grimm, Michael Pharmaceutics Article Sparkling water is said to increase gastric motility by the release of carbon dioxide, thereby potentially affecting the pharmacokinetics of orally administered drugs. The hypothesis of the present work was that the induction of gastric motility by intragastric release of carbon dioxide from effervescent granules could promote the mixing of drugs into the chyme under postprandial conditions, resulting in a prolonged drug absorption. For this purpose, an effervescent and a non-effervescent granule formulation of caffeine as a marker for gastric emptying were developed. In a three-way crossover study with twelve healthy volunteers, the salivary caffeine pharmacokinetics, after administration of the effervescent granules with still water and the administration of the non-effervescent granules with still and sparkling water, were investigated after intake of a standard meal. While the administration of the effervescent granules with 240 mL of still water led to a significantly prolonged gastric residence of the substance compared to the administration of the non-effervescent granules with 240 mL still water, the application of the non-effervescent granules with 240 mL sparkling water did not prolong gastric residence via mixing into caloric chyme. Overall, the mixing of caffeine into the chyme following the administration of the effervescent granules did not seem to be a motility mediated process. MDPI 2023-03-22 /pmc/articles/PMC10056953/ /pubmed/36986872 http://dx.doi.org/10.3390/pharmaceutics15031012 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Senekowitsch, Stefan Foja, Constantin Wildgrube, Toni Schick, Philipp Rosenbaum, Christoph Krause, Julius Brokmann, Friederike Kromrey, Marie-Luise Engeli, Stefan Weitschies, Werner Grimm, Michael Intragastric Carbon Dioxide Release Prolongs the Gastric Residence Time of Postprandially Administered Caffeine |
title | Intragastric Carbon Dioxide Release Prolongs the Gastric Residence Time of Postprandially Administered Caffeine |
title_full | Intragastric Carbon Dioxide Release Prolongs the Gastric Residence Time of Postprandially Administered Caffeine |
title_fullStr | Intragastric Carbon Dioxide Release Prolongs the Gastric Residence Time of Postprandially Administered Caffeine |
title_full_unstemmed | Intragastric Carbon Dioxide Release Prolongs the Gastric Residence Time of Postprandially Administered Caffeine |
title_short | Intragastric Carbon Dioxide Release Prolongs the Gastric Residence Time of Postprandially Administered Caffeine |
title_sort | intragastric carbon dioxide release prolongs the gastric residence time of postprandially administered caffeine |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10056953/ https://www.ncbi.nlm.nih.gov/pubmed/36986872 http://dx.doi.org/10.3390/pharmaceutics15031012 |
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