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Mechanochemical Synergism of Reactive Oxygen Species Influences on RBC Membrane
The influences of various factors on blood lead to the formation of extra reactive oxygen species (ROS), resulting in the disruption of morphology and functions of red blood cells (RBCs). This study considers the mechanisms of the mechanochemical synergism of [Formula: see text] free radicals, which...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057059/ https://www.ncbi.nlm.nih.gov/pubmed/36983026 http://dx.doi.org/10.3390/ijms24065952 |
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author | Kozlova, Elena Sergunova, Viktoria Sherstyukova, Ekaterina Grechko, Andrey Lyapunova, Snezhanna Inozemtsev, Vladimir Kozlov, Aleksandr Gudkova, Olga Chernysh, Aleksandr |
author_facet | Kozlova, Elena Sergunova, Viktoria Sherstyukova, Ekaterina Grechko, Andrey Lyapunova, Snezhanna Inozemtsev, Vladimir Kozlov, Aleksandr Gudkova, Olga Chernysh, Aleksandr |
author_sort | Kozlova, Elena |
collection | PubMed |
description | The influences of various factors on blood lead to the formation of extra reactive oxygen species (ROS), resulting in the disruption of morphology and functions of red blood cells (RBCs). This study considers the mechanisms of the mechanochemical synergism of [Formula: see text] free radicals, which are most active in the initiation of lipid peroxidation (LPO) in RBC membranes, and [Formula: see text] molecules, the largest typical diffusion path. Using kinetic models of differential equations describing [Formula: see text] and [Formula: see text] , we discuss two levels of mechanochemical synergism that occur simultaneously: (1) synergism that ensures the delivery of highly active free radicals [Formula: see text] to RBC membranes and (2) a positive feedback system between [Formula: see text] and [Formula: see text] , resulting in the partial restoration of spent molecules. As a result of these ROS synergisms, the efficiency of LPO in RBC membranes sharply increases. In blood, the appearance of [Formula: see text] free radicals is due to the interaction of [Formula: see text] molecules with free iron ions ([Formula: see text]) which arise as a result of heme degradation. We experimentally established the quantitative dependences of [Formula: see text] using the methods of spectrophotometry and nonlinear curve fitting. This study extends the analysis of the influence of ROS mechanisms in RBC suspensions. |
format | Online Article Text |
id | pubmed-10057059 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100570592023-03-30 Mechanochemical Synergism of Reactive Oxygen Species Influences on RBC Membrane Kozlova, Elena Sergunova, Viktoria Sherstyukova, Ekaterina Grechko, Andrey Lyapunova, Snezhanna Inozemtsev, Vladimir Kozlov, Aleksandr Gudkova, Olga Chernysh, Aleksandr Int J Mol Sci Article The influences of various factors on blood lead to the formation of extra reactive oxygen species (ROS), resulting in the disruption of morphology and functions of red blood cells (RBCs). This study considers the mechanisms of the mechanochemical synergism of [Formula: see text] free radicals, which are most active in the initiation of lipid peroxidation (LPO) in RBC membranes, and [Formula: see text] molecules, the largest typical diffusion path. Using kinetic models of differential equations describing [Formula: see text] and [Formula: see text] , we discuss two levels of mechanochemical synergism that occur simultaneously: (1) synergism that ensures the delivery of highly active free radicals [Formula: see text] to RBC membranes and (2) a positive feedback system between [Formula: see text] and [Formula: see text] , resulting in the partial restoration of spent molecules. As a result of these ROS synergisms, the efficiency of LPO in RBC membranes sharply increases. In blood, the appearance of [Formula: see text] free radicals is due to the interaction of [Formula: see text] molecules with free iron ions ([Formula: see text]) which arise as a result of heme degradation. We experimentally established the quantitative dependences of [Formula: see text] using the methods of spectrophotometry and nonlinear curve fitting. This study extends the analysis of the influence of ROS mechanisms in RBC suspensions. MDPI 2023-03-21 /pmc/articles/PMC10057059/ /pubmed/36983026 http://dx.doi.org/10.3390/ijms24065952 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kozlova, Elena Sergunova, Viktoria Sherstyukova, Ekaterina Grechko, Andrey Lyapunova, Snezhanna Inozemtsev, Vladimir Kozlov, Aleksandr Gudkova, Olga Chernysh, Aleksandr Mechanochemical Synergism of Reactive Oxygen Species Influences on RBC Membrane |
title | Mechanochemical Synergism of Reactive Oxygen Species Influences on RBC Membrane |
title_full | Mechanochemical Synergism of Reactive Oxygen Species Influences on RBC Membrane |
title_fullStr | Mechanochemical Synergism of Reactive Oxygen Species Influences on RBC Membrane |
title_full_unstemmed | Mechanochemical Synergism of Reactive Oxygen Species Influences on RBC Membrane |
title_short | Mechanochemical Synergism of Reactive Oxygen Species Influences on RBC Membrane |
title_sort | mechanochemical synergism of reactive oxygen species influences on rbc membrane |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057059/ https://www.ncbi.nlm.nih.gov/pubmed/36983026 http://dx.doi.org/10.3390/ijms24065952 |
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