Effects of 4′-Demethylnobiletin and 4′-Demethyltangeretin on Osteoclast Differentiation In Vitro and in a Mouse Model of Estrogen-Deficient Bone Resorption

Citrus nobiletin (NOB) and tangeretin (TAN) show protective effects against disease-related bone destruction. We achieved demethylation of NOB and TAN into 4′-demethylnobiletin (4′-DN) and 4′-demethyltangeretin (4′-DT) using enzyme-manufacturing methods. In this study, we examined the effects of 4′-...

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Detalles Bibliográficos
Autores principales: Hirata, Michiko, Tominari, Tsukasa, Ichimaru, Ryota, Takiguchi, Naruhiko, Tanaka, Yuki, Takatoya, Masaru, Arai, Daichi, Yoshinouchi, Shosei, Miyaura, Chisato, Matsumoto, Chiho, Ma, Sihui, Suzuki, Katsuhiko, Grundler, Florian M. W., Inada, Masaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057105/
https://www.ncbi.nlm.nih.gov/pubmed/36986133
http://dx.doi.org/10.3390/nu15061403

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