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H(2)O(2)-PLA-(Alg)(2)Ca Hydrogel Enriched in Matrigel(®) Promotes Diabetic Wound Healing
Hydrogel-based dressings exhibit suitable features for successful wound healing, including flexibility, high water-vapor permeability and moisture retention, and exudate absorption capacity. Moreover, enriching the hydrogel matrix with additional therapeutic components has the potential to generate...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057140/ https://www.ncbi.nlm.nih.gov/pubmed/36986719 http://dx.doi.org/10.3390/pharmaceutics15030857 |
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author | Bîrcă, Alexandra Cătălina Chircov, Cristina Niculescu, Adelina Gabriela Hildegard, Herman Baltă, Cornel Roșu, Marcel Mladin, Bianca Gherasim, Oana Mihaiescu, Dan Eduard Vasile, Bogdan Ștefan Grumezescu, Alexandru Mihai Andronescu, Ecaterina Hermenean, Anca Oana |
author_facet | Bîrcă, Alexandra Cătălina Chircov, Cristina Niculescu, Adelina Gabriela Hildegard, Herman Baltă, Cornel Roșu, Marcel Mladin, Bianca Gherasim, Oana Mihaiescu, Dan Eduard Vasile, Bogdan Ștefan Grumezescu, Alexandru Mihai Andronescu, Ecaterina Hermenean, Anca Oana |
author_sort | Bîrcă, Alexandra Cătălina |
collection | PubMed |
description | Hydrogel-based dressings exhibit suitable features for successful wound healing, including flexibility, high water-vapor permeability and moisture retention, and exudate absorption capacity. Moreover, enriching the hydrogel matrix with additional therapeutic components has the potential to generate synergistic results. Thus, the present study centered on diabetic wound healing using a Matrigel-enriched alginate hydrogel embedded with polylactic acid (PLA) microspheres containing hydrogen peroxide (H(2)O(2)). The synthesis and physicochemical characterization of the samples, performed to evidence their compositional and microstructural features, swelling, and oxygen-entrapping capacity, were reported. For investigating the three-fold goal of the designed dressings (i.e., releasing oxygen at the wound site and maintaining a moist environment for faster healing, ensuring the absorption of a significant amount of exudate, and providing biocompatibility), in vivo biological tests on wounds of diabetic mice were approached. Evaluating multiple aspects during the healing process, the obtained composite material proved its efficiency for wound dressing applications by accelerating wound healing and promoting angiogenesis in diabetic skin injuries. |
format | Online Article Text |
id | pubmed-10057140 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100571402023-03-30 H(2)O(2)-PLA-(Alg)(2)Ca Hydrogel Enriched in Matrigel(®) Promotes Diabetic Wound Healing Bîrcă, Alexandra Cătălina Chircov, Cristina Niculescu, Adelina Gabriela Hildegard, Herman Baltă, Cornel Roșu, Marcel Mladin, Bianca Gherasim, Oana Mihaiescu, Dan Eduard Vasile, Bogdan Ștefan Grumezescu, Alexandru Mihai Andronescu, Ecaterina Hermenean, Anca Oana Pharmaceutics Article Hydrogel-based dressings exhibit suitable features for successful wound healing, including flexibility, high water-vapor permeability and moisture retention, and exudate absorption capacity. Moreover, enriching the hydrogel matrix with additional therapeutic components has the potential to generate synergistic results. Thus, the present study centered on diabetic wound healing using a Matrigel-enriched alginate hydrogel embedded with polylactic acid (PLA) microspheres containing hydrogen peroxide (H(2)O(2)). The synthesis and physicochemical characterization of the samples, performed to evidence their compositional and microstructural features, swelling, and oxygen-entrapping capacity, were reported. For investigating the three-fold goal of the designed dressings (i.e., releasing oxygen at the wound site and maintaining a moist environment for faster healing, ensuring the absorption of a significant amount of exudate, and providing biocompatibility), in vivo biological tests on wounds of diabetic mice were approached. Evaluating multiple aspects during the healing process, the obtained composite material proved its efficiency for wound dressing applications by accelerating wound healing and promoting angiogenesis in diabetic skin injuries. MDPI 2023-03-06 /pmc/articles/PMC10057140/ /pubmed/36986719 http://dx.doi.org/10.3390/pharmaceutics15030857 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Bîrcă, Alexandra Cătălina Chircov, Cristina Niculescu, Adelina Gabriela Hildegard, Herman Baltă, Cornel Roșu, Marcel Mladin, Bianca Gherasim, Oana Mihaiescu, Dan Eduard Vasile, Bogdan Ștefan Grumezescu, Alexandru Mihai Andronescu, Ecaterina Hermenean, Anca Oana H(2)O(2)-PLA-(Alg)(2)Ca Hydrogel Enriched in Matrigel(®) Promotes Diabetic Wound Healing |
title | H(2)O(2)-PLA-(Alg)(2)Ca Hydrogel Enriched in Matrigel(®) Promotes Diabetic Wound Healing |
title_full | H(2)O(2)-PLA-(Alg)(2)Ca Hydrogel Enriched in Matrigel(®) Promotes Diabetic Wound Healing |
title_fullStr | H(2)O(2)-PLA-(Alg)(2)Ca Hydrogel Enriched in Matrigel(®) Promotes Diabetic Wound Healing |
title_full_unstemmed | H(2)O(2)-PLA-(Alg)(2)Ca Hydrogel Enriched in Matrigel(®) Promotes Diabetic Wound Healing |
title_short | H(2)O(2)-PLA-(Alg)(2)Ca Hydrogel Enriched in Matrigel(®) Promotes Diabetic Wound Healing |
title_sort | h(2)o(2)-pla-(alg)(2)ca hydrogel enriched in matrigel(®) promotes diabetic wound healing |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057140/ https://www.ncbi.nlm.nih.gov/pubmed/36986719 http://dx.doi.org/10.3390/pharmaceutics15030857 |
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