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False-Positive Serology for Rocky Mountain Spotted Fever in Long Island, New York, during 2011–2021

Cases of rocky mountain spotted fever (RMSF) are increasingly reported every year in Long Island, New York. In clinical practice, an uncommonly high number of referrals with a positive RMSF IgG test result have been seen in our tick-borne disease clinic. The aim of this study is to describe the clin...

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Autores principales: Sajib, Monirul I., Lamba, Pooja, Spitzer, Eric D., Marcos, Luis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057202/
https://www.ncbi.nlm.nih.gov/pubmed/36986426
http://dx.doi.org/10.3390/pathogens12030503
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author Sajib, Monirul I.
Lamba, Pooja
Spitzer, Eric D.
Marcos, Luis A.
author_facet Sajib, Monirul I.
Lamba, Pooja
Spitzer, Eric D.
Marcos, Luis A.
author_sort Sajib, Monirul I.
collection PubMed
description Cases of rocky mountain spotted fever (RMSF) are increasingly reported every year in Long Island, New York. In clinical practice, an uncommonly high number of referrals with a positive RMSF IgG test result have been seen in our tick-borne disease clinic. The aim of this study is to describe the clinical–epidemiological characteristics and outcomes of hospitalized patients with positive serologies for RMSF in our academic center in Long Island, NY. We found that out of twenty-four patients with a positive serology for RMSF, only one case met the case definition per CDC criteria, two had suspected RMSF, and the other twenty-one did not have a clinical picture consistent with RMSF. A high number of false-positive RMSF serology may be due to other spotted fever rickettsioses in Long Island. Further studies are needed to investigate the presence of another Rickettsia spp. (such as Rickettsia amblyommatis) in this area that may affect humans.
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spelling pubmed-100572022023-03-30 False-Positive Serology for Rocky Mountain Spotted Fever in Long Island, New York, during 2011–2021 Sajib, Monirul I. Lamba, Pooja Spitzer, Eric D. Marcos, Luis A. Pathogens Article Cases of rocky mountain spotted fever (RMSF) are increasingly reported every year in Long Island, New York. In clinical practice, an uncommonly high number of referrals with a positive RMSF IgG test result have been seen in our tick-borne disease clinic. The aim of this study is to describe the clinical–epidemiological characteristics and outcomes of hospitalized patients with positive serologies for RMSF in our academic center in Long Island, NY. We found that out of twenty-four patients with a positive serology for RMSF, only one case met the case definition per CDC criteria, two had suspected RMSF, and the other twenty-one did not have a clinical picture consistent with RMSF. A high number of false-positive RMSF serology may be due to other spotted fever rickettsioses in Long Island. Further studies are needed to investigate the presence of another Rickettsia spp. (such as Rickettsia amblyommatis) in this area that may affect humans. MDPI 2023-03-22 /pmc/articles/PMC10057202/ /pubmed/36986426 http://dx.doi.org/10.3390/pathogens12030503 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sajib, Monirul I.
Lamba, Pooja
Spitzer, Eric D.
Marcos, Luis A.
False-Positive Serology for Rocky Mountain Spotted Fever in Long Island, New York, during 2011–2021
title False-Positive Serology for Rocky Mountain Spotted Fever in Long Island, New York, during 2011–2021
title_full False-Positive Serology for Rocky Mountain Spotted Fever in Long Island, New York, during 2011–2021
title_fullStr False-Positive Serology for Rocky Mountain Spotted Fever in Long Island, New York, during 2011–2021
title_full_unstemmed False-Positive Serology for Rocky Mountain Spotted Fever in Long Island, New York, during 2011–2021
title_short False-Positive Serology for Rocky Mountain Spotted Fever in Long Island, New York, during 2011–2021
title_sort false-positive serology for rocky mountain spotted fever in long island, new york, during 2011–2021
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057202/
https://www.ncbi.nlm.nih.gov/pubmed/36986426
http://dx.doi.org/10.3390/pathogens12030503
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