Increased Enzyme Loading in PICsomes via Controlling Membrane Permeability Improves Enzyme Prodrug Cancer Therapy Outcome

Mesoscopic-sized polyion complex vesicles (PICsomes) with semi-permeable membranes are promising nanoreactors for enzyme prodrug therapy (EPT), mainly due to their ability to accommodate enzymes in their inner cavity. Increased loading efficacy and retained activity of enzymes in PICsomes are crucia...

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Detalles Bibliográficos
Autores principales: Goto, Akinori, Anraku, Yasutaka, Fukushima, Shigeto, Kishimura, Akihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057300/
https://www.ncbi.nlm.nih.gov/pubmed/36987149
http://dx.doi.org/10.3390/polym15061368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057300/
https://www.ncbi.nlm.nih.gov/pubmed/36987149
http://dx.doi.org/10.3390/polym15061368

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