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Objective Classification of Glistening in Implanted Intraocular Lenses Using Optical Coherence Tomography: Proposal for a New Classification and Grading System

Purpose: To propose a classification of the glistening in intraocular lenses (IOL) using swept-source optical coherence tomography (SS-OCT) by means of a simple, objective and reproducible method that allows the quantification of the presence and severity of glistening. Methods: A cross-sectional st...

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Autores principales: Fernández-Vigo, José Ignacio, Burgos-Blasco, Bárbara, De-Pablo-Gómez-de-Liaño, Lucía, Sánchez-Guillén, Inés, Albitre-Barca, Virginia, Fernández-Aragón, Susana, Fernández-Vigo, José Ángel, Macarro-Merino, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057385/
https://www.ncbi.nlm.nih.gov/pubmed/36983351
http://dx.doi.org/10.3390/jcm12062351
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author Fernández-Vigo, José Ignacio
Burgos-Blasco, Bárbara
De-Pablo-Gómez-de-Liaño, Lucía
Sánchez-Guillén, Inés
Albitre-Barca, Virginia
Fernández-Aragón, Susana
Fernández-Vigo, José Ángel
Macarro-Merino, Ana
author_facet Fernández-Vigo, José Ignacio
Burgos-Blasco, Bárbara
De-Pablo-Gómez-de-Liaño, Lucía
Sánchez-Guillén, Inés
Albitre-Barca, Virginia
Fernández-Aragón, Susana
Fernández-Vigo, José Ángel
Macarro-Merino, Ana
author_sort Fernández-Vigo, José Ignacio
collection PubMed
description Purpose: To propose a classification of the glistening in intraocular lenses (IOL) using swept-source optical coherence tomography (SS-OCT) by means of a simple, objective and reproducible method that allows the quantification of the presence and severity of glistening. Methods: A cross-sectional study on a sample of 150 eyes of 150 patients who underwent cataract surgery in at least 600 days before the exam and attended a routine examination. Each subject was examined by SS-OCT after pupil dilation, identifying the presence of glistening or hyperreflective foci (HRF) in the central area of the IOL. The degree of glistening was classified into four categories: 0: ≤5 HRF; 1: 6 to 15 HRF; 2: 16 to 30 HRF; and 3: >30 HRF. The intra and interobserver reproducibility (intraclass correlation coefficient, ICC) in the quantification and classification of the glistening were calculated. The correlation between the horizontal and vertical scan of the IOL was also assessed. Results: Glistening was present in the IOL in 42.7% of the patients. The mean number of HRF or glistening microvacuoles was 10.4 ± 26.2 (range 0 to 239). In total, 63.3% of the IOLs had a grade 0, 20% grade a 1, 6.7% grade a 2 and 10% a grade 3. The intraobserver and interobserver reproducibility were very high, both for the absolute quantification of the glistening (ICC ≥ 0.994) and for the severity scale (ICC ≥ 0.967). There was an excellent correlation in the quantification of the IOL glistening between the horizontal and vertical scans (R ≥ 0.834; p < 0.001). Conclusions: The use of SS-OCT makes it possible to identify, quantify and classify IOL glistening in a simple, objective and reproducible way. This technique could provide relevant information for the study of the glistening on IOLs.
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spelling pubmed-100573852023-03-30 Objective Classification of Glistening in Implanted Intraocular Lenses Using Optical Coherence Tomography: Proposal for a New Classification and Grading System Fernández-Vigo, José Ignacio Burgos-Blasco, Bárbara De-Pablo-Gómez-de-Liaño, Lucía Sánchez-Guillén, Inés Albitre-Barca, Virginia Fernández-Aragón, Susana Fernández-Vigo, José Ángel Macarro-Merino, Ana J Clin Med Article Purpose: To propose a classification of the glistening in intraocular lenses (IOL) using swept-source optical coherence tomography (SS-OCT) by means of a simple, objective and reproducible method that allows the quantification of the presence and severity of glistening. Methods: A cross-sectional study on a sample of 150 eyes of 150 patients who underwent cataract surgery in at least 600 days before the exam and attended a routine examination. Each subject was examined by SS-OCT after pupil dilation, identifying the presence of glistening or hyperreflective foci (HRF) in the central area of the IOL. The degree of glistening was classified into four categories: 0: ≤5 HRF; 1: 6 to 15 HRF; 2: 16 to 30 HRF; and 3: >30 HRF. The intra and interobserver reproducibility (intraclass correlation coefficient, ICC) in the quantification and classification of the glistening were calculated. The correlation between the horizontal and vertical scan of the IOL was also assessed. Results: Glistening was present in the IOL in 42.7% of the patients. The mean number of HRF or glistening microvacuoles was 10.4 ± 26.2 (range 0 to 239). In total, 63.3% of the IOLs had a grade 0, 20% grade a 1, 6.7% grade a 2 and 10% a grade 3. The intraobserver and interobserver reproducibility were very high, both for the absolute quantification of the glistening (ICC ≥ 0.994) and for the severity scale (ICC ≥ 0.967). There was an excellent correlation in the quantification of the IOL glistening between the horizontal and vertical scans (R ≥ 0.834; p < 0.001). Conclusions: The use of SS-OCT makes it possible to identify, quantify and classify IOL glistening in a simple, objective and reproducible way. This technique could provide relevant information for the study of the glistening on IOLs. MDPI 2023-03-17 /pmc/articles/PMC10057385/ /pubmed/36983351 http://dx.doi.org/10.3390/jcm12062351 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fernández-Vigo, José Ignacio
Burgos-Blasco, Bárbara
De-Pablo-Gómez-de-Liaño, Lucía
Sánchez-Guillén, Inés
Albitre-Barca, Virginia
Fernández-Aragón, Susana
Fernández-Vigo, José Ángel
Macarro-Merino, Ana
Objective Classification of Glistening in Implanted Intraocular Lenses Using Optical Coherence Tomography: Proposal for a New Classification and Grading System
title Objective Classification of Glistening in Implanted Intraocular Lenses Using Optical Coherence Tomography: Proposal for a New Classification and Grading System
title_full Objective Classification of Glistening in Implanted Intraocular Lenses Using Optical Coherence Tomography: Proposal for a New Classification and Grading System
title_fullStr Objective Classification of Glistening in Implanted Intraocular Lenses Using Optical Coherence Tomography: Proposal for a New Classification and Grading System
title_full_unstemmed Objective Classification of Glistening in Implanted Intraocular Lenses Using Optical Coherence Tomography: Proposal for a New Classification and Grading System
title_short Objective Classification of Glistening in Implanted Intraocular Lenses Using Optical Coherence Tomography: Proposal for a New Classification and Grading System
title_sort objective classification of glistening in implanted intraocular lenses using optical coherence tomography: proposal for a new classification and grading system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057385/
https://www.ncbi.nlm.nih.gov/pubmed/36983351
http://dx.doi.org/10.3390/jcm12062351
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