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IFN-Induced PARPs—Sensors of Foreign Nucleic Acids?

Cells have developed different strategies to cope with viral infections. Key to initiating a defense response against viruses is the ability to distinguish foreign molecules from their own. One central mechanism is the perception of foreign nucleic acids by host proteins which, in turn, initiate an...

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Autores principales: Biaesch, Katharina, Knapp, Sarah, Korn, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057411/
https://www.ncbi.nlm.nih.gov/pubmed/36986379
http://dx.doi.org/10.3390/pathogens12030457
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author Biaesch, Katharina
Knapp, Sarah
Korn, Patricia
author_facet Biaesch, Katharina
Knapp, Sarah
Korn, Patricia
author_sort Biaesch, Katharina
collection PubMed
description Cells have developed different strategies to cope with viral infections. Key to initiating a defense response against viruses is the ability to distinguish foreign molecules from their own. One central mechanism is the perception of foreign nucleic acids by host proteins which, in turn, initiate an efficient immune response. Nucleic acid sensing pattern recognition receptors have evolved, each targeting specific features to discriminate viral from host RNA. These are complemented by several RNA-binding proteins that assist in sensing of foreign RNAs. There is increasing evidence that the interferon-inducible ADP-ribosyltransferases (ARTs; PARP9—PARP15) contribute to immune defense and attenuation of viruses. However, their activation, subsequent targets, and precise mechanisms of interference with viruses and their propagation are still largely unknown. Best known for its antiviral activities and its role as RNA sensor is PARP13. In addition, PARP9 has been recently described as sensor for viral RNA. Here we will discuss recent findings suggesting that some PARPs function in antiviral innate immunity. We expand on these findings and integrate this information into a concept that outlines how the different PARPs might function as sensors of foreign RNA. We speculate about possible consequences of RNA binding with regard to the catalytic activities of PARPs, substrate specificity and signaling, which together result in antiviral activities.
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spelling pubmed-100574112023-03-30 IFN-Induced PARPs—Sensors of Foreign Nucleic Acids? Biaesch, Katharina Knapp, Sarah Korn, Patricia Pathogens Review Cells have developed different strategies to cope with viral infections. Key to initiating a defense response against viruses is the ability to distinguish foreign molecules from their own. One central mechanism is the perception of foreign nucleic acids by host proteins which, in turn, initiate an efficient immune response. Nucleic acid sensing pattern recognition receptors have evolved, each targeting specific features to discriminate viral from host RNA. These are complemented by several RNA-binding proteins that assist in sensing of foreign RNAs. There is increasing evidence that the interferon-inducible ADP-ribosyltransferases (ARTs; PARP9—PARP15) contribute to immune defense and attenuation of viruses. However, their activation, subsequent targets, and precise mechanisms of interference with viruses and their propagation are still largely unknown. Best known for its antiviral activities and its role as RNA sensor is PARP13. In addition, PARP9 has been recently described as sensor for viral RNA. Here we will discuss recent findings suggesting that some PARPs function in antiviral innate immunity. We expand on these findings and integrate this information into a concept that outlines how the different PARPs might function as sensors of foreign RNA. We speculate about possible consequences of RNA binding with regard to the catalytic activities of PARPs, substrate specificity and signaling, which together result in antiviral activities. MDPI 2023-03-14 /pmc/articles/PMC10057411/ /pubmed/36986379 http://dx.doi.org/10.3390/pathogens12030457 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Biaesch, Katharina
Knapp, Sarah
Korn, Patricia
IFN-Induced PARPs—Sensors of Foreign Nucleic Acids?
title IFN-Induced PARPs—Sensors of Foreign Nucleic Acids?
title_full IFN-Induced PARPs—Sensors of Foreign Nucleic Acids?
title_fullStr IFN-Induced PARPs—Sensors of Foreign Nucleic Acids?
title_full_unstemmed IFN-Induced PARPs—Sensors of Foreign Nucleic Acids?
title_short IFN-Induced PARPs—Sensors of Foreign Nucleic Acids?
title_sort ifn-induced parps—sensors of foreign nucleic acids?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057411/
https://www.ncbi.nlm.nih.gov/pubmed/36986379
http://dx.doi.org/10.3390/pathogens12030457
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