RSV A2-Based Prefusion F Vaccine Candidates Induce RSV A and RSV B Cross Binding and Neutralizing Antibodies and Provide Protection against RSV A and RSV B Challenge in Preclinical Models

RSV is divided into two antigenic subtypes, RSV A and RSV B, which is largely based on the variation in the G protein, while the fusion protein F is more conserved and a target for antibody-mediated neutralization. Here we evaluate the breadth of the protective immune responses across RSV A and RSV...

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Detalles Bibliográficos
Autores principales: Cox, Freek, Saeland, Eirikur, Thoma, Anne, van den Hoogen, Ward, Tettero, Lisanne, Drijver, Joke, Vaneman, Cornelis, van Polanen, Yolinda, Ritschel, Tina, Bastian, Arangassery Rosemary, Callendret, Benoit, Zahn, Roland, van der Fits, Leslie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057437/
https://www.ncbi.nlm.nih.gov/pubmed/36992257
http://dx.doi.org/10.3390/vaccines11030672

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