Cargando…
The Impact of Vitamin D Levels on Clinical Manifestations of Multisystem Inflammatory Syndrome in Children: A Cross-Sectional Study
Background: Hyperinflammatory response that resembles Kawasaki disease may develop in children after COVID-19 disease, and it is called multisystem inflammatory syndrome in children. The cause of MIS-C is dysregulated innate immune response and a subsequent cytokine storm that results in endothelial...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057472/ https://www.ncbi.nlm.nih.gov/pubmed/36983830 http://dx.doi.org/10.3390/life13030674 |
_version_ | 1785016375647928320 |
---|---|
author | Petrovic, Davor Benzon, Benjamin Srsen, Sasa Polic, Branka Vukovic Novogradec, Antonija Milic, Petra Markic, Josko |
author_facet | Petrovic, Davor Benzon, Benjamin Srsen, Sasa Polic, Branka Vukovic Novogradec, Antonija Milic, Petra Markic, Josko |
author_sort | Petrovic, Davor |
collection | PubMed |
description | Background: Hyperinflammatory response that resembles Kawasaki disease may develop in children after COVID-19 disease, and it is called multisystem inflammatory syndrome in children. The cause of MIS-C is dysregulated innate immune response and a subsequent cytokine storm that results in endothelial damage. It has been determined that low levels of serum 25(OH)D increase the risk of developing immune-related diseases and disorders. Methods: To determine the incidence of hypovitaminosis D, and a possible correlation between 25(OH)D levels and the clinical severity of MIS-C, 21 patients hospitalized in the University Hospital of Split due to MIS-C were evaluated. Results: Hypovitaminosis D was detected in 95% of MIS-C patients. We found a significant relationship between the severity of MIS-C and 25(OH)D levels, as patients with more severe MIS-C had lower 25(OH)D. MIS-C patients with lower vitamin D levels had worse systolic and diastolic function of the left ventricle according to echocardiograms. There was no relationship between 25(OH)D levels and the tested laboratory inflammatory and cardiac markers. Conclusion: Hypovitaminosis D is very common in children with MIS-C and influences the severity of the disease. VD could be a new potential biomarker in MIS-C, and VD replacement therapy should be considered early on in the treatment of MIS-C. |
format | Online Article Text |
id | pubmed-10057472 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-100574722023-03-30 The Impact of Vitamin D Levels on Clinical Manifestations of Multisystem Inflammatory Syndrome in Children: A Cross-Sectional Study Petrovic, Davor Benzon, Benjamin Srsen, Sasa Polic, Branka Vukovic Novogradec, Antonija Milic, Petra Markic, Josko Life (Basel) Article Background: Hyperinflammatory response that resembles Kawasaki disease may develop in children after COVID-19 disease, and it is called multisystem inflammatory syndrome in children. The cause of MIS-C is dysregulated innate immune response and a subsequent cytokine storm that results in endothelial damage. It has been determined that low levels of serum 25(OH)D increase the risk of developing immune-related diseases and disorders. Methods: To determine the incidence of hypovitaminosis D, and a possible correlation between 25(OH)D levels and the clinical severity of MIS-C, 21 patients hospitalized in the University Hospital of Split due to MIS-C were evaluated. Results: Hypovitaminosis D was detected in 95% of MIS-C patients. We found a significant relationship between the severity of MIS-C and 25(OH)D levels, as patients with more severe MIS-C had lower 25(OH)D. MIS-C patients with lower vitamin D levels had worse systolic and diastolic function of the left ventricle according to echocardiograms. There was no relationship between 25(OH)D levels and the tested laboratory inflammatory and cardiac markers. Conclusion: Hypovitaminosis D is very common in children with MIS-C and influences the severity of the disease. VD could be a new potential biomarker in MIS-C, and VD replacement therapy should be considered early on in the treatment of MIS-C. MDPI 2023-03-01 /pmc/articles/PMC10057472/ /pubmed/36983830 http://dx.doi.org/10.3390/life13030674 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Petrovic, Davor Benzon, Benjamin Srsen, Sasa Polic, Branka Vukovic Novogradec, Antonija Milic, Petra Markic, Josko The Impact of Vitamin D Levels on Clinical Manifestations of Multisystem Inflammatory Syndrome in Children: A Cross-Sectional Study |
title | The Impact of Vitamin D Levels on Clinical Manifestations of Multisystem Inflammatory Syndrome in Children: A Cross-Sectional Study |
title_full | The Impact of Vitamin D Levels on Clinical Manifestations of Multisystem Inflammatory Syndrome in Children: A Cross-Sectional Study |
title_fullStr | The Impact of Vitamin D Levels on Clinical Manifestations of Multisystem Inflammatory Syndrome in Children: A Cross-Sectional Study |
title_full_unstemmed | The Impact of Vitamin D Levels on Clinical Manifestations of Multisystem Inflammatory Syndrome in Children: A Cross-Sectional Study |
title_short | The Impact of Vitamin D Levels on Clinical Manifestations of Multisystem Inflammatory Syndrome in Children: A Cross-Sectional Study |
title_sort | impact of vitamin d levels on clinical manifestations of multisystem inflammatory syndrome in children: a cross-sectional study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057472/ https://www.ncbi.nlm.nih.gov/pubmed/36983830 http://dx.doi.org/10.3390/life13030674 |
work_keys_str_mv | AT petrovicdavor theimpactofvitamindlevelsonclinicalmanifestationsofmultisysteminflammatorysyndromeinchildrenacrosssectionalstudy AT benzonbenjamin theimpactofvitamindlevelsonclinicalmanifestationsofmultisysteminflammatorysyndromeinchildrenacrosssectionalstudy AT srsensasa theimpactofvitamindlevelsonclinicalmanifestationsofmultisysteminflammatorysyndromeinchildrenacrosssectionalstudy AT policbranka theimpactofvitamindlevelsonclinicalmanifestationsofmultisysteminflammatorysyndromeinchildrenacrosssectionalstudy AT vukovicnovogradecantonija theimpactofvitamindlevelsonclinicalmanifestationsofmultisysteminflammatorysyndromeinchildrenacrosssectionalstudy AT milicpetra theimpactofvitamindlevelsonclinicalmanifestationsofmultisysteminflammatorysyndromeinchildrenacrosssectionalstudy AT markicjosko theimpactofvitamindlevelsonclinicalmanifestationsofmultisysteminflammatorysyndromeinchildrenacrosssectionalstudy AT petrovicdavor impactofvitamindlevelsonclinicalmanifestationsofmultisysteminflammatorysyndromeinchildrenacrosssectionalstudy AT benzonbenjamin impactofvitamindlevelsonclinicalmanifestationsofmultisysteminflammatorysyndromeinchildrenacrosssectionalstudy AT srsensasa impactofvitamindlevelsonclinicalmanifestationsofmultisysteminflammatorysyndromeinchildrenacrosssectionalstudy AT policbranka impactofvitamindlevelsonclinicalmanifestationsofmultisysteminflammatorysyndromeinchildrenacrosssectionalstudy AT vukovicnovogradecantonija impactofvitamindlevelsonclinicalmanifestationsofmultisysteminflammatorysyndromeinchildrenacrosssectionalstudy AT milicpetra impactofvitamindlevelsonclinicalmanifestationsofmultisysteminflammatorysyndromeinchildrenacrosssectionalstudy AT markicjosko impactofvitamindlevelsonclinicalmanifestationsofmultisysteminflammatorysyndromeinchildrenacrosssectionalstudy |