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Distinctive Signs of Disease as Deterrents for the Endothelial Function: A Systematic Review

Endothelial integrity plays a major role in homeostasis and is responsive to the numerous endogenous factors released. While its functional role in vascular tone is well described, its role in the pathophysiology of cardiovascular disease is of interest as a potential therapeutic target. We performe...

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Detalles Bibliográficos
Autores principales: Nappi, Francesco, Avtaar Singh, Sanjeet Singh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057506/
https://www.ncbi.nlm.nih.gov/pubmed/36984870
http://dx.doi.org/10.3390/metabo13030430
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author Nappi, Francesco
Avtaar Singh, Sanjeet Singh
author_facet Nappi, Francesco
Avtaar Singh, Sanjeet Singh
author_sort Nappi, Francesco
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description Endothelial integrity plays a major role in homeostasis and is responsive to the numerous endogenous factors released. While its functional role in vascular tone is well described, its role in the pathophysiology of cardiovascular disease is of interest as a potential therapeutic target. We performed a systematic review to provide an overview of new therapeutic and diagnostic targets for the treatment of coronary artery disease related to endothelial dysfunction. Databases of PubMed, Ovid’s version of MEDLINE, and EMBASE were interrogated with appropriate search terms. Inclusion criteria have been met by 28 studies that were included in the final systematic review. We identified inflammation, pulmonary hypertension, diabetes mellitus and Fabry disease as pathophysiological mechanisms and explored the therapeutic options related to these conditions including medications such as Canakinumab. Endothelial dysfunction has a key role in several different pathophysiological processes which can be targeted for therapeutic options. Ongoing research should be targeted at making the transition to clinical practice. Further research is also needed on understanding the amelioration of endothelial dysfunction with the use of cardiovascular medications.
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spelling pubmed-100575062023-03-30 Distinctive Signs of Disease as Deterrents for the Endothelial Function: A Systematic Review Nappi, Francesco Avtaar Singh, Sanjeet Singh Metabolites Systematic Review Endothelial integrity plays a major role in homeostasis and is responsive to the numerous endogenous factors released. While its functional role in vascular tone is well described, its role in the pathophysiology of cardiovascular disease is of interest as a potential therapeutic target. We performed a systematic review to provide an overview of new therapeutic and diagnostic targets for the treatment of coronary artery disease related to endothelial dysfunction. Databases of PubMed, Ovid’s version of MEDLINE, and EMBASE were interrogated with appropriate search terms. Inclusion criteria have been met by 28 studies that were included in the final systematic review. We identified inflammation, pulmonary hypertension, diabetes mellitus and Fabry disease as pathophysiological mechanisms and explored the therapeutic options related to these conditions including medications such as Canakinumab. Endothelial dysfunction has a key role in several different pathophysiological processes which can be targeted for therapeutic options. Ongoing research should be targeted at making the transition to clinical practice. Further research is also needed on understanding the amelioration of endothelial dysfunction with the use of cardiovascular medications. MDPI 2023-03-16 /pmc/articles/PMC10057506/ /pubmed/36984870 http://dx.doi.org/10.3390/metabo13030430 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Nappi, Francesco
Avtaar Singh, Sanjeet Singh
Distinctive Signs of Disease as Deterrents for the Endothelial Function: A Systematic Review
title Distinctive Signs of Disease as Deterrents for the Endothelial Function: A Systematic Review
title_full Distinctive Signs of Disease as Deterrents for the Endothelial Function: A Systematic Review
title_fullStr Distinctive Signs of Disease as Deterrents for the Endothelial Function: A Systematic Review
title_full_unstemmed Distinctive Signs of Disease as Deterrents for the Endothelial Function: A Systematic Review
title_short Distinctive Signs of Disease as Deterrents for the Endothelial Function: A Systematic Review
title_sort distinctive signs of disease as deterrents for the endothelial function: a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057506/
https://www.ncbi.nlm.nih.gov/pubmed/36984870
http://dx.doi.org/10.3390/metabo13030430
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