A Conserved Acidic Residue in the C-Terminal Flexible Loop of HIV-1 Nef Contributes to the Activity of SERINC5 and CD4 Downregulation

The host transmembrane protein SERINC5 is incorporated into retrovirus particles and inhibits HIV-1 infectivity. The lentiviral Nef protein counteracts SERINC5 by downregulating it from the cell surface and preventing its incorporation into virions. The ability of Nef to antagonize the host factor v...

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Detalles Bibliográficos
Autores principales: Firrito, Claudia, Bertelli, Cinzia, Rosa, Annachiara, Chande, Ajit, Ananth, Swetha, van Dijk, Hannah, Fackler, Oliver T., Stoneham, Charlotte, Singh, Rajendra, Guatelli, John, Pizzato, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057511/
https://www.ncbi.nlm.nih.gov/pubmed/36992361
http://dx.doi.org/10.3390/v15030652

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