Cargando…

Surfing the Waves: Differences in Hospitalised COVID-19 Patients across 4 Variant Waves in a Belgian University Hospital

The unprecedented COVID-19 pandemic took the form of successive variant waves, spreading across the globe. We wanted to investigate any shift in hospitalised patients’ profiles throughout the pandemic. For this study, we used a registry that collected data automatically from electronic patient healt...

Descripción completa

Detalles Bibliográficos
Autores principales: Seyler, Lucie, Van Nedervelde, Els, De Cock, Diederik, Mann, Claudia, Pien, Karen, Allard, Sabine D., Demuyser, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057609/
https://www.ncbi.nlm.nih.gov/pubmed/36992327
http://dx.doi.org/10.3390/v15030618
_version_ 1785016411214577664
author Seyler, Lucie
Van Nedervelde, Els
De Cock, Diederik
Mann, Claudia
Pien, Karen
Allard, Sabine D.
Demuyser, Thomas
author_facet Seyler, Lucie
Van Nedervelde, Els
De Cock, Diederik
Mann, Claudia
Pien, Karen
Allard, Sabine D.
Demuyser, Thomas
author_sort Seyler, Lucie
collection PubMed
description The unprecedented COVID-19 pandemic took the form of successive variant waves, spreading across the globe. We wanted to investigate any shift in hospitalised patients’ profiles throughout the pandemic. For this study, we used a registry that collected data automatically from electronic patient health records. We compared clinical data and severity scores, using the National Institute of Health (NIH) severity scores, from all patients admitted for COVID-19 during four SARS-CoV-2 variant waves. Our study concluded that patients hospitalised for COVID-19 showed very different profiles across the four variant waves in Belgium. Patients were younger during the Alpha and Delta waves and frailer during the Omicron period. ‘Critical’ patients according to the NIH criteria formed the largest fraction among the Alpha wave patients (47.7%), while ‘severe’ patients formed the largest fraction among Omicron patients (61.6%). We discussed host factors, vaccination status, and other confounders to put this into perspective. High-quality real-life data remain crucial to inform stakeholders and policymakers that shifts in patients’ clinical profiles have an impact on clinical practice.
format Online
Article
Text
id pubmed-10057609
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-100576092023-03-30 Surfing the Waves: Differences in Hospitalised COVID-19 Patients across 4 Variant Waves in a Belgian University Hospital Seyler, Lucie Van Nedervelde, Els De Cock, Diederik Mann, Claudia Pien, Karen Allard, Sabine D. Demuyser, Thomas Viruses Article The unprecedented COVID-19 pandemic took the form of successive variant waves, spreading across the globe. We wanted to investigate any shift in hospitalised patients’ profiles throughout the pandemic. For this study, we used a registry that collected data automatically from electronic patient health records. We compared clinical data and severity scores, using the National Institute of Health (NIH) severity scores, from all patients admitted for COVID-19 during four SARS-CoV-2 variant waves. Our study concluded that patients hospitalised for COVID-19 showed very different profiles across the four variant waves in Belgium. Patients were younger during the Alpha and Delta waves and frailer during the Omicron period. ‘Critical’ patients according to the NIH criteria formed the largest fraction among the Alpha wave patients (47.7%), while ‘severe’ patients formed the largest fraction among Omicron patients (61.6%). We discussed host factors, vaccination status, and other confounders to put this into perspective. High-quality real-life data remain crucial to inform stakeholders and policymakers that shifts in patients’ clinical profiles have an impact on clinical practice. MDPI 2023-02-23 /pmc/articles/PMC10057609/ /pubmed/36992327 http://dx.doi.org/10.3390/v15030618 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Seyler, Lucie
Van Nedervelde, Els
De Cock, Diederik
Mann, Claudia
Pien, Karen
Allard, Sabine D.
Demuyser, Thomas
Surfing the Waves: Differences in Hospitalised COVID-19 Patients across 4 Variant Waves in a Belgian University Hospital
title Surfing the Waves: Differences in Hospitalised COVID-19 Patients across 4 Variant Waves in a Belgian University Hospital
title_full Surfing the Waves: Differences in Hospitalised COVID-19 Patients across 4 Variant Waves in a Belgian University Hospital
title_fullStr Surfing the Waves: Differences in Hospitalised COVID-19 Patients across 4 Variant Waves in a Belgian University Hospital
title_full_unstemmed Surfing the Waves: Differences in Hospitalised COVID-19 Patients across 4 Variant Waves in a Belgian University Hospital
title_short Surfing the Waves: Differences in Hospitalised COVID-19 Patients across 4 Variant Waves in a Belgian University Hospital
title_sort surfing the waves: differences in hospitalised covid-19 patients across 4 variant waves in a belgian university hospital
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057609/
https://www.ncbi.nlm.nih.gov/pubmed/36992327
http://dx.doi.org/10.3390/v15030618
work_keys_str_mv AT seylerlucie surfingthewavesdifferencesinhospitalisedcovid19patientsacross4variantwavesinabelgianuniversityhospital
AT vannederveldeels surfingthewavesdifferencesinhospitalisedcovid19patientsacross4variantwavesinabelgianuniversityhospital
AT decockdiederik surfingthewavesdifferencesinhospitalisedcovid19patientsacross4variantwavesinabelgianuniversityhospital
AT mannclaudia surfingthewavesdifferencesinhospitalisedcovid19patientsacross4variantwavesinabelgianuniversityhospital
AT pienkaren surfingthewavesdifferencesinhospitalisedcovid19patientsacross4variantwavesinabelgianuniversityhospital
AT allardsabined surfingthewavesdifferencesinhospitalisedcovid19patientsacross4variantwavesinabelgianuniversityhospital
AT demuyserthomas surfingthewavesdifferencesinhospitalisedcovid19patientsacross4variantwavesinabelgianuniversityhospital